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Mast cell sarcoma of the scalp: the first sign of undisclosed systemic mastocytosis?
- Source :
-
Pathology, research and practice [Pathol Res Pract] 2012 Nov 15; Vol. 208 (11), pp. 683-6. Date of Electronic Publication: 2012 Sep 07. - Publication Year :
- 2012
-
Abstract
- Mastocytosis is a neoplastic disease of mast cells and their CD34+ precursors, including a heterogeneous group of disorders. It is characterized by abnormal growth and accumulation of mast cells in one or more organ systems. Mast cell sarcoma is an extremely rare and aggressive disease characterized by local proliferation of atypical mast cells, destructive growth and poor prognosis, without systemic involvement. Very few clinical cases describing this entity have been reported in the literature. In this paper, we report a case of a mast cell sarcoma, localized in the scalp of a 63-year-old woman; it appears to be the first manifestation of undisclosed systemic mastocytosis.<br /> (Copyright © 2012 Elsevier GmbH. All rights reserved.)
- Subjects :
- Biomarkers, Tumor metabolism
DNA Mutational Analysis
DNA, Neoplasm analysis
Diagnosis, Differential
Female
Head and Neck Neoplasms etiology
Head and Neck Neoplasms metabolism
Head and Neck Neoplasms surgery
Humans
Mast-Cell Sarcoma etiology
Mast-Cell Sarcoma metabolism
Mast-Cell Sarcoma surgery
Mastocytosis, Systemic complications
Mastocytosis, Systemic metabolism
Middle Aged
Mutation
Proto-Oncogene Proteins c-kit genetics
Proto-Oncogene Proteins c-kit metabolism
Skin Neoplasms etiology
Skin Neoplasms metabolism
Skin Neoplasms surgery
Head and Neck Neoplasms diagnosis
Mast Cells pathology
Mast-Cell Sarcoma diagnosis
Mastocytosis, Systemic diagnosis
Scalp
Skin Neoplasms diagnosis
Subjects
Details
- Language :
- English
- ISSN :
- 1618-0631
- Volume :
- 208
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Pathology, research and practice
- Publication Type :
- Academic Journal
- Accession number :
- 22963840
- Full Text :
- https://doi.org/10.1016/j.prp.2012.06.010