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A new entry to the construction of a quaternary carbon center having a fluorine atom--S(N)2' reaction of γ-fluoroallylic alcohol derivatives with various cyanocuprates.
- Source :
-
Organic & biomolecular chemistry [Org Biomol Chem] 2012 Oct 28; Vol. 10 (40), pp. 8154-63. - Publication Year :
- 2012
-
Abstract
- Treatment of γ-fluoroallylic phosphate with various lower-ordered cyanocuprates derived from Grignard reagents, organolithium, and organozincs gave the corresponding S(N)2' products having a fluorine atom at a quaternary carbon center in excellent yields. This system could be successfully extended to the chiral version, enantiomerically pure fluorine-containing materials also being obtained in high yield.
Details
- Language :
- English
- ISSN :
- 1477-0539
- Volume :
- 10
- Issue :
- 40
- Database :
- MEDLINE
- Journal :
- Organic & biomolecular chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 22965477
- Full Text :
- https://doi.org/10.1039/c2ob25718a