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[Primary biliary cirrhosis (PBC)].
- Source :
-
Duodecim; laaketieteellinen aikakauskirja [Duodecim] 2012; Vol. 128 (15), pp. 1550-9. - Publication Year :
- 2012
-
Abstract
- Primary biliary cirrhosis (PBC) is an inflammatory autoimmune liver disease leading, if untreated, to cholestasis and cirrhosis. The diagnosis is made on the basis of elevated plasma levels of alkaline phosphatase and antimitochondrial antibodies at a stage where the patient usually still remains symptomless. The degree of severity and prognosis of the disease are defined by means of histological findings of the liver. Adequate response for approximately half of the patients is obtained with urodeoxycholic acid treatment. The treatment for advanced disease is hepatic transplantation, which yields excellent results.
- Subjects :
- Alkaline Phosphatase blood
Biomarkers blood
Cholagogues and Choleretics therapeutic use
Humans
Liver Cirrhosis, Biliary complications
Liver Transplantation
Mitochondria, Liver immunology
Prognosis
Ursodeoxycholic Acid therapeutic use
Liver Cirrhosis, Biliary diagnosis
Liver Cirrhosis, Biliary therapy
Subjects
Details
- Language :
- Finnish
- ISSN :
- 0012-7183
- Volume :
- 128
- Issue :
- 15
- Database :
- MEDLINE
- Journal :
- Duodecim; laaketieteellinen aikakauskirja
- Publication Type :
- Academic Journal
- Accession number :
- 22970606