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Antimicrobial treatment and containment measures for an extremely drug-resistant Klebsiella pneumoniae ST101 isolate carrying pKPN101-IT, a novel fully sequenced bla(KPC-2) plasmid.
- Source :
-
Journal of clinical microbiology [J Clin Microbiol] 2012 Nov; Vol. 50 (11), pp. 3768-72. Date of Electronic Publication: 2012 Sep 12. - Publication Year :
- 2012
-
Abstract
- An extremely drug-resistant Klebsiella pneumoniae isolate, sequence type ST101, was isolated from a patient in Italy. We describe antibiotic treatment, measures to clear and contain the infection, and a complete sequence analysis of a novel large plasmid, pKPN101-IT, harboring the bla(KPC-2) gene and arising from the threatening recombination of different worldwide-distributed backbones.
- Subjects :
- Anti-Bacterial Agents pharmacology
DNA, Bacterial chemistry
DNA, Bacterial genetics
Humans
Italy
Klebsiella pneumoniae enzymology
Klebsiella pneumoniae genetics
Klebsiella pneumoniae isolation & purification
Male
Middle Aged
Molecular Sequence Data
Plasmids
Sequence Analysis, DNA
beta-Lactamases genetics
Anti-Bacterial Agents administration & dosage
Drug Resistance, Multiple, Bacterial
Infection Control methods
Klebsiella Infections drug therapy
Klebsiella Infections microbiology
Klebsiella pneumoniae drug effects
beta-Lactamases metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1098-660X
- Volume :
- 50
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Journal of clinical microbiology
- Publication Type :
- Academic Journal
- Accession number :
- 22972824
- Full Text :
- https://doi.org/10.1128/JCM.01892-12