Effect of recombinant erythropoietin on functional activity of cultured human cells.

Authors :: Emel'yanova EA
Kosykh AV
Sukhanov YV
Vorotelyak EA
Vasil'ev AV
Source :: Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2012 Aug; Vol. 153 (4), pp. 554-8.
Publication Year :: 2012
Abstract: We studied the effect of recombinant human erythropoietin on functional activity of skin cells in vitro. It was found that erythropoietin stimulated proliferation of mesenchymal and epithelial cells and effectively protected epidermal HaCaT cells from apoptosis. Insignificant effect of erythropoietin on contraction of collagen gel by mesenchymal cells was revealed. These findings suggest that erythropoietin can be a promising component of wound-healing preparations.

Subjects :: Cell Line
Cells, Cultured
Collagen drug effects
Epithelial Cells drug effects
Fibroblasts drug effects
Gels
Humans
In Situ Nick-End Labeling
Keratinocytes drug effects
Mesoderm cytology
Stromal Cells drug effects
Time Factors
Adipose Tissue drug effects
Apoptosis drug effects
Cell Proliferation drug effects
Erythropoietin pharmacology
Mesoderm drug effects
Recombinant Proteins pharmacology

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