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Gaps in the prevention of perinatal transmission of hepatitis B virus between recommendations and routine practices in a highly endemic region: a provincial population-based study in China.
- Source :
-
BMC infectious diseases [BMC Infect Dis] 2012 Sep 17; Vol. 12, pp. 221. Date of Electronic Publication: 2012 Sep 17. - Publication Year :
- 2012
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Abstract
- Background: Hepatitis B virus (HBV) infection is endemic in China; perinatal transmission is the main source of chronic HBV infection. Simultaneous administration of hepatitis B immune globulin (HBIG) and hepatitis B vaccine is highly effective to prevent perinatal transmission of HBV; however, the effectiveness also depends on full adherence to the recommended protocols in daily practice. In the present investigation, we aimed to identify gaps in immunoprophylaxis of perinatal transmission of HBV between recommendations and routine practices in Jiangsu Province, China.<br />Methods: Totally 626 children from 6 cities and 8 rural areas across Jiangsu Province, China, born from February 2003 to December 2004, were enrolled; 298 were born to mothers with positive hepatitis B surface antigen (HBsAg) and 328 were born to HBsAg-negative mothers. Immunoprophylactic measures against hepatitis B were retrospectively reviewed for about half of the children by checking medical records or vaccination cards and the vaccine status was validated for most of children.<br />Results: Of 298 children born to HBV carrier mothers, 11 (3.7%) were HBsAg positive, while none of 328 children born to non-carrier mothers was HBsAg positive (P < 0.01). The rates of anti-HBs ≥ 10 mIU/ml in children of carrier and non-carrier mothers were 69.5% and 69.2% respectively (P = 0.95). The hepatitis B vaccine coverage in two groups was 100% and 99.4% respectively (P = 0.50), but 15.1% of HBV-exposed infants did not receive the timely birth dose. Prenatal HBsAg screening was performed only in 156 (52.3%) of the carrier mothers. Consequently, only 112 (37.6%) of HBV-exposed infants received HBIG after birth. Furthermore, of the 11 HBV-infected children, only one received both HBIG and hepatitis B vaccine timely, seven missed HBIG, two received delayed vaccination, and one missed HBIG and received delayed vaccination.<br />Conclusions: There are substantial gaps in the prevention of perinatal HBV infection between the recommendations and routine practices in China, which highlights the importance of full adherence to the recommendations to eliminate perinatal HBV infection in the endemic regions.
- Subjects :
- Adult
Chemoprevention methods
China
Female
Hepatitis B epidemiology
Hepatitis B Antibodies administration & dosage
Hepatitis B Vaccines administration & dosage
Humans
Immunoglobulins, Intravenous administration & dosage
Infant, Newborn
Male
Pregnancy
Pregnancy Complications, Infectious epidemiology
Pregnancy Complications, Infectious prevention & control
Retrospective Studies
Young Adult
Communicable Disease Control methods
Endemic Diseases
Guideline Adherence statistics & numerical data
Hepatitis B prevention & control
Hepatitis B transmission
Infectious Disease Transmission, Vertical prevention & control
Subjects
Details
- Language :
- English
- ISSN :
- 1471-2334
- Volume :
- 12
- Database :
- MEDLINE
- Journal :
- BMC infectious diseases
- Publication Type :
- Academic Journal
- Accession number :
- 22984924
- Full Text :
- https://doi.org/10.1186/1471-2334-12-221