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Bcl6 expression specifies the T follicular helper cell program in vivo.
- Source :
-
The Journal of experimental medicine [J Exp Med] 2012 Sep 24; Vol. 209 (10), pp. 1841-52, S1-24. Date of Electronic Publication: 2012 Sep 17. - Publication Year :
- 2012
-
Abstract
- T follicular helper cells (Tfh cells) play a pivotal role in germinal center reactions, which require B cell lymphoma 6 (Bcl6) transcription factor. To analyze their relationships with other effector T cell lineages and their stability in vivo, we developed and analyzed a new Bcl6 reporter mouse alone or together with other lineage reporter systems. Assisted with genome-wide transcriptome analysis, we show substantial plasticity of T cell differentiation in the early phase of immune response. At this stage, CXCR5 appears to be expressed in a Bcl6-independent manner. Once Bcl6 is highly expressed, Tfh cells can persist in vivo and some of them develop into memory cells. Together, our results indicate Bcl6 as a bona fide marker for Tfh polarized program.
- Subjects :
- Animals
Antibody Formation immunology
Cell Differentiation immunology
Cluster Analysis
DNA-Binding Proteins immunology
Gene Expression
Gene Expression Profiling
Gene Order
Gene Targeting
Genes, Reporter
Germinal Center immunology
Immunologic Memory
Mice
Mice, Transgenic
Proto-Oncogene Proteins c-bcl-6
Receptors, CXCR5 genetics
Receptors, CXCR5 metabolism
T-Lymphocyte Subsets cytology
T-Lymphocyte Subsets immunology
T-Lymphocyte Subsets metabolism
T-Lymphocytes, Helper-Inducer cytology
T-Lymphocytes, Helper-Inducer metabolism
Transcription, Genetic
DNA-Binding Proteins genetics
T-Lymphocytes, Helper-Inducer immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1540-9538
- Volume :
- 209
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- The Journal of experimental medicine
- Publication Type :
- Academic Journal
- Accession number :
- 22987803
- Full Text :
- https://doi.org/10.1084/jem.20120219