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The Aryl Hydrocarbon Receptor Influences Transplant Outcomes in Response to Environmental Signals.
The Aryl Hydrocarbon Receptor Influences Transplant Outcomes in Response to Environmental Signals.
- Source :
-
Toxicological and environmental chemistry [Toxicol Environ Chem] 2012; Vol. 94 (6), pp. 1175-1187. Date of Electronic Publication: 2012 Jun 20. - Publication Year :
- 2012
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Abstract
- The aryl hydrocarbon receptor (AHR) is a cytosolic transcription factor with numerous endogenous and xenobiotic ligands, most notably 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Recent data suggests that TCDD may induce regulatory T cells, while a second AHR ligand, FICZ, promotes Th17 differentiation. The aim was to examine whether injection of recipient mice with either TCDD or FICZ altered skin allograft rejection in a fully mismatched model. TCDD or FICZ was given to recipient C57BL/6 mice intraperitoneally (IP). Twenty-four hr later, donor skin was grafted from BALB/c mice. An additional dose of FICZ was given on day 3. Treatment with TCDD delayed graft rejection for more than 4 weeks while FICZ treatment accelerated rejection by 1 - 2 days. In vivo exposure with TCDD led to a rise in the frequency of FoxP3(+) CD4(+) T cells in the spleen, while FICZ increased IL-17 secretion by splenocytes from treated animals. Activation of the AHR receptor by different AHR ligands in vivo resulted in opposing effects on skin graft survival. AHR serves as a sensor to environmental signals, with effects on the acquired immune system that may alter outcomes after organ transplantation. This model will be useful to further delineate direct effects of the environment on the immune system and outcomes of organ transplantation.
Details
- Language :
- English
- ISSN :
- 0277-2248
- Volume :
- 94
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Toxicological and environmental chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 23002321
- Full Text :
- https://doi.org/10.1080/02772248.2012.688546