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The beneficial effect of high-dose mizoribine combined with cyclosporine, basiliximab, and corticosteroids on CMV infection in renal transplant recipients.
- Source :
-
Clinical and experimental nephrology [Clin Exp Nephrol] 2013 Feb; Vol. 17 (1), pp. 127-33. Date of Electronic Publication: 2012 Aug 02. - Publication Year :
- 2013
-
Abstract
- Background: Mizoribine (MZR) has been developed as an immunosuppressive agent, but has a less potent immunosuppressive effect up to 3 mg/kg/day MZR. Therefore, we investigated whether high-dose MZR, at 6 mg/kg/day, would be effective and safe for kidney transplant patients in conjunction with cyclosporine (CsA), basiliximab, and corticosteroids.<br />Methods: A total of 40 living related patients were administered MZR (6 mg/kg/day), CsA (7 mg/kg/day), prednisolone (maintenance dose 10 mg/day), and basiliximab (20 mg/body). A control group (n = 38) treated with CsA, mycophenolate mofetil (MMF, 25 mg/kg/day), basiliximab, and corticosteroids was also employed in this study.<br />Results: The 2-year graft survival rates for the MZR and MMF groups were 100 and 94.7 %, respectively. The rejection rate in the MZR group (25 %) was not significantly higher than that in the MMF group (16 %). Serum creatinine level was not significant between the two groups. The number of patients who developed cytomegalovirus (CMV) disease was 0 (0 %) in the MZR group and 7 (18.4 %) in the MMF group (P < 0.05). The number of patients treated with ganciclovir was 3 (7.5 %) and 11 (28.9 %) (P < 0.05), respectively.<br />Conclusions: The combination of high-dose MZR with CsA, basiliximab, and corticosteroids can establish not only satisfactory immunosuppression but also a low rate of CMV infection in vivo.
- Subjects :
- Adrenal Cortex Hormones adverse effects
Adult
Antibodies, Monoclonal adverse effects
Antiviral Agents therapeutic use
Basiliximab
Biomarkers blood
Creatinine blood
Cyclosporine adverse effects
Cytomegalovirus Infections drug therapy
Cytomegalovirus Infections immunology
Cytomegalovirus Infections virology
Drug Therapy, Combination
Female
Ganciclovir therapeutic use
Graft Rejection immunology
Graft Rejection prevention & control
Graft Survival drug effects
Humans
Immunosuppressive Agents adverse effects
Immunosuppressive Agents pharmacokinetics
Kaplan-Meier Estimate
Kidney Transplantation adverse effects
Living Donors
Male
Middle Aged
Recombinant Fusion Proteins adverse effects
Ribonucleosides adverse effects
Ribonucleosides pharmacokinetics
Treatment Outcome
Young Adult
Adrenal Cortex Hormones administration & dosage
Antibodies, Monoclonal administration & dosage
Cyclosporine administration & dosage
Cytomegalovirus Infections prevention & control
Immunosuppressive Agents administration & dosage
Kidney Transplantation immunology
Recombinant Fusion Proteins administration & dosage
Ribonucleosides administration & dosage
Subjects
Details
- Language :
- English
- ISSN :
- 1437-7799
- Volume :
- 17
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Clinical and experimental nephrology
- Publication Type :
- Academic Journal
- Accession number :
- 23011290
- Full Text :
- https://doi.org/10.1007/s10157-012-0669-4