Back to Search
Start Over
Plasma alemtuzumab levels in patients with chronic lymphocytic leukemia treated with alemtuzumab combined with chemotherapy reflect the efficacy of the treatment: a hypothesis.
- Source :
-
Leukemia & lymphoma [Leuk Lymphoma] 2013 Apr; Vol. 54 (4), pp. 790-3. Date of Electronic Publication: 2013 Jan 04. - Publication Year :
- 2013
-
Abstract
- In the HOVON68 trial comparing subcutaneous low-dose alemtuzumab (LD-A) used together with fludarabine (F) and cyclophosphamide (C) with FC alone in high-risk chronic lymphocytic leukemia (CLL), LD-AFC resulted in significantly more clinical and molecular responses than FC, but also in more opportunistic infections. In a subgroup analysis of alemtuzumab trough levels during treatment by a sensitive enzyme-linked immunosorbent assay (ELISA) method, detectable levels were found in 4/6 complete and 0/3 partial responders. A relationship between alemtuzumab plasma levels, response and duration of lymphocytopenia was evident. We hypothesize that following combination therapy, the response may not be a function of the alemtuzumab levels, but the opposite, that plasma alemtuzumab levels are a function of the efficacy of the entire treatment, and the fewer leukemic target cells that are remaining, the higher are the levels of plasma alemtuzumab. This concept may well provide a guide for alemtuzumab dosage in future trials.
- Subjects :
- Alemtuzumab
Antibodies, Monoclonal, Humanized administration & dosage
Antibodies, Monoclonal, Humanized blood
Antineoplastic Combined Chemotherapy Protocols adverse effects
Humans
Induction Chemotherapy
Leukemia, Lymphocytic, Chronic, B-Cell blood
Lymphopenia chemically induced
Prognosis
Treatment Outcome
Antineoplastic Combined Chemotherapy Protocols therapeutic use
Leukemia, Lymphocytic, Chronic, B-Cell drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1029-2403
- Volume :
- 54
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Leukemia & lymphoma
- Publication Type :
- Academic Journal
- Accession number :
- 23025267
- Full Text :
- https://doi.org/10.3109/10428194.2012.720373