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Surfactant protein A associated with respiratory distress syndrome in Korean preterm infants: evidence of ethnic difference.
- Source :
-
Neonatology [Neonatology] 2013; Vol. 103 (1), pp. 44-7. Date of Electronic Publication: 2012 Oct 03. - Publication Year :
- 2013
-
Abstract
- Background: Insufficiency of the pulmonary surfactant system is the primary cause of respiratory distress syndrome (RDS) in preterm infants. Genetic factors, including specific single-nucleotide polymorphisms in the genetic components of surfactant protein A (SP-A1 and SP-A2), affect protein structure and function, as well as risk of RDS.<br />Objective: We investigated the association between variations in SP-A genotypes and RDS within the genetically homogeneous Korean population.<br />Methods: We used TaqMan® real-time polymerase chain reaction technology to assess nine single-nucleotide polymorphisms of SP-A in 261 full-term and 152 preterm infants. Among the preterm infants, 76 infants with RDS were matched with 76 control infants with respect to gestation, use of antenatal steroids and gender.<br />Results: The SP-A2 1A(0) variant and the homozygous 1A(0)/1A(0) genotype were associated with protection from RDS (OR 0.31, 95% CI 0.13-0.78). In addition, the 1A(1) carrier genotype (containing one copy of the 1A(1) variant) was associated with increased risk of RDS (OR 2.42, 95% CI 1.06-5.52). The significance of these results is that the association of patterns with RDS was opposite to the findings of previous research with Finnish and North American study populations.<br />Conclusions: We have identified associations between specific variants of the SP-A genes and RDS risk in the Korean preterm study population. Our data strongly support SP-A as a candidate gene for susceptibility to RDS, and reveal the dissimilarity of the associated risk/protective genetic variants between different ethnic study populations.<br /> (Copyright © 2012 S. Karger AG, Basel.)
- Subjects :
- Base Sequence
Case-Control Studies
Female
Gene Frequency
Genetic Association Studies
Humans
Infant, Newborn
Infant, Premature
Infant, Premature, Diseases ethnology
Male
Polymorphism, Single Nucleotide physiology
Republic of Korea
Respiratory Distress Syndrome, Newborn ethnology
Asian People genetics
Genetic Predisposition to Disease ethnology
Infant, Premature, Diseases genetics
Pulmonary Surfactant-Associated Protein A genetics
Respiratory Distress Syndrome, Newborn genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1661-7819
- Volume :
- 103
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Neonatology
- Publication Type :
- Academic Journal
- Accession number :
- 23038062
- Full Text :
- https://doi.org/10.1159/000342498