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Surfactant protein A associated with respiratory distress syndrome in Korean preterm infants: evidence of ethnic difference.

Authors :
Jo HS
Cho SI
Chang YH
Kim BI
Choi JH
Source :
Neonatology [Neonatology] 2013; Vol. 103 (1), pp. 44-7. Date of Electronic Publication: 2012 Oct 03.
Publication Year :
2013

Abstract

Background: Insufficiency of the pulmonary surfactant system is the primary cause of respiratory distress syndrome (RDS) in preterm infants. Genetic factors, including specific single-nucleotide polymorphisms in the genetic components of surfactant protein A (SP-A1 and SP-A2), affect protein structure and function, as well as risk of RDS.<br />Objective: We investigated the association between variations in SP-A genotypes and RDS within the genetically homogeneous Korean population.<br />Methods: We used TaqMan® real-time polymerase chain reaction technology to assess nine single-nucleotide polymorphisms of SP-A in 261 full-term and 152 preterm infants. Among the preterm infants, 76 infants with RDS were matched with 76 control infants with respect to gestation, use of antenatal steroids and gender.<br />Results: The SP-A2 1A(0) variant and the homozygous 1A(0)/1A(0) genotype were associated with protection from RDS (OR 0.31, 95% CI 0.13-0.78). In addition, the 1A(1) carrier genotype (containing one copy of the 1A(1) variant) was associated with increased risk of RDS (OR 2.42, 95% CI 1.06-5.52). The significance of these results is that the association of patterns with RDS was opposite to the findings of previous research with Finnish and North American study populations.<br />Conclusions: We have identified associations between specific variants of the SP-A genes and RDS risk in the Korean preterm study population. Our data strongly support SP-A as a candidate gene for susceptibility to RDS, and reveal the dissimilarity of the associated risk/protective genetic variants between different ethnic study populations.<br /> (Copyright © 2012 S. Karger AG, Basel.)

Details

Language :
English
ISSN :
1661-7819
Volume :
103
Issue :
1
Database :
MEDLINE
Journal :
Neonatology
Publication Type :
Academic Journal
Accession number :
23038062
Full Text :
https://doi.org/10.1159/000342498