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Relationship between autoantibody clustering and clinical subsets in SLE: cluster and association analyses in Hong Kong Chinese.
- Source :
-
Rheumatology (Oxford, England) [Rheumatology (Oxford)] 2013 Feb; Vol. 52 (2), pp. 337-45. Date of Electronic Publication: 2012 Oct 04. - Publication Year :
- 2013
-
Abstract
- Objective: This study aims to identify the existence of, and relationship between autoantibody clusters and clinical subsets in Chinese SLE patients.<br />Methods: Data from 1928 SLE patients from Hong Kong were analysed. Using cluster analysis, patients were grouped by autoantibodies into clusters. The frequencies of various clinical manifestations were then compared between each cluster. Separate association analyses between individual autoantibodies and clinical manifestations as well as between clinical manifestations were also performed without any prior clustering.<br />Results: Three separate autoantibody clusters were identified, each with significantly different clinical manifestations. Cluster 1 was characterized by anti-dsDNA and the greatest prevalence of renal disorder but the lowest frequencies of other clinical manifestations. Cluster 2 was represented by the predominance of anti-Smith, anti-RNP and aPL, with greater prevalence of malar rash, oral ulcers, arthritis and serositis. Cluster 3 was characterized by anti-Ro and anti-La with greater prevalence of discoid rash, photosensitivity and haematological involvement. Individual association analysis also revealed similar findings. Patients of clusters 2 and 3 were more closely related, while cluster 1 was more distinct, associated with renal disorder only and negatively associated or not associated with other manifestations.<br />Conclusion: We conclude that autoantibody clustering and clinical subsets exist in SLE patients of our locality. These clusters may be viewed as a bipolar spectrum of related autoantibody and clinical manifestations. At one end are patients with over-representation of anti-dsDNA and renal disorder, while at the other end are two distinct autoantibody clusters (anti-Sm/anti-RNP/aPL and anti-Ro/anti-La) with overlapping of other clinical manifestations.
- Subjects :
- Adolescent
Adult
Antibodies, Antinuclear blood
Asian People ethnology
Cluster Analysis
Cross-Sectional Studies
Female
Hong Kong epidemiology
Humans
Lupus Erythematosus, Systemic ethnology
Male
Prevalence
Retrospective Studies
Young Adult
Autoantibodies blood
Lupus Erythematosus, Systemic immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1462-0332
- Volume :
- 52
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Rheumatology (Oxford, England)
- Publication Type :
- Academic Journal
- Accession number :
- 23038697
- Full Text :
- https://doi.org/10.1093/rheumatology/kes261