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Association between donor and recipient TCF7L2 gene polymorphisms and the risk of new-onset diabetes mellitus after liver transplantation in a Han Chinese population.
- Source :
-
Journal of hepatology [J Hepatol] 2013 Feb; Vol. 58 (2), pp. 271-7. Date of Electronic Publication: 2012 Oct 04. - Publication Year :
- 2013
-
Abstract
- Backgrounds & Aims: New-onset diabetes mellitus (NODM) is a frequent and serious complication arising after liver transplantation (LT). Transcription factor 7-like 2 (TCF7L2) polymorphisms have been reported to strongly associate with type 2 diabetes. In addition, the donor liver plays a vital role in regulating blood glucose levels. In this study, we aim at evaluating the association between donor and recipient TCF7L2 gene polymorphisms with NODM after LT.<br />Methods: A total of 125 patients undergoing primary LT, without a history of diabetes were included. Four single nucleotide polymorphisms (rs290487, rs7903146, rs11196205, and rs12255372), closely associated with type 2 diabetes in the Eastern Asia population, were genotyped and analyzed.<br />Results: Both donor and recipient rs290487 polymorphisms (CC vs. TT genotype) were found to be significantly associated with NODM. In multivariate analysis, donor rs290487 genetic variation (OR = 2.172 per each C allele, p = 0.015), blood tacrolimus levels at 1 month post-LT >10 ng/ml (OR = 3.264, p = 0.017), and recipient age >55 years (OR = 2.638, p = 0.043) were identified as independent risk factors of NODM. Furthermore, donor rs290487 CC genotype could predict a high probability (>40%) of the onset of NODM. Predictive model containing donor rs290487 polymorphism showed a significantly higher prognostic ability on NODM than the model with only clinical parameters (p = 0.031).<br />Conclusions: Donor TCF7L2 rs290487 polymorphism is associated with an increased risk of NODM after LT and has a potential clinical value for the prediction of NODM.<br /> (Copyright © 2012 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.)
- Subjects :
- Adult
Asian People ethnology
China epidemiology
Diabetes Mellitus, Type 2 epidemiology
Diabetes Mellitus, Type 2 ethnology
Female
Gene Frequency genetics
Genetic Predisposition to Disease ethnology
Genotype
Humans
Logistic Models
Male
Middle Aged
Models, Statistical
Risk Factors
Asian People genetics
Diabetes Mellitus, Type 2 genetics
Genetic Predisposition to Disease genetics
Liver Transplantation
Polymorphism, Single Nucleotide genetics
Tissue Donors
Transcription Factor 7-Like 2 Protein genetics
Transplantation
Subjects
Details
- Language :
- English
- ISSN :
- 1600-0641
- Volume :
- 58
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Journal of hepatology
- Publication Type :
- Academic Journal
- Accession number :
- 23041303
- Full Text :
- https://doi.org/10.1016/j.jhep.2012.09.025