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Enabling Wittig reaction on site-specific protein modification.
- Source :
-
Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2012 Nov 21; Vol. 48 (90), pp. 11079-81. Date of Electronic Publication: 2012 Oct 05. - Publication Year :
- 2012
-
Abstract
- An efficient aqueous Wittig reaction was enabled on protein bioconjugation for the first time. By investigating the reaction on small molecules, peptides, and proteins, a site-specific reaction targeting "aldehyde tag" was presented. A variety of functional groups could be introduced into the protein of interest.
Details
- Language :
- English
- ISSN :
- 1364-548X
- Volume :
- 48
- Issue :
- 90
- Database :
- MEDLINE
- Journal :
- Chemical communications (Cambridge, England)
- Publication Type :
- Academic Journal
- Accession number :
- 23042100
- Full Text :
- https://doi.org/10.1039/c2cc35738k