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Antibacterial activity of substituted dibenzo[a,g]quinolizin-7-ium derivatives.
- Source :
-
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2012 Nov 15; Vol. 22 (22), pp. 6962-6. Date of Electronic Publication: 2012 Sep 20. - Publication Year :
- 2012
-
Abstract
- Berberine is a substituted dibenzo[a,g]quinolizin-7-ium derivative whose modest antibiotic activity is derived from its disruptive impact on the function of the essential bacterial cell division protein FtsZ. The present study reveals that the presence of a biphenyl substituent at either the 2- or 12-position of structurally-related dibenzo[a,g]quinolizin-7-ium derivatives significantly enhances antibacterial potency versus Staphylococcus aureus and Enterococcus faecalis. Studies with purified S. aureus FtsZ demonstrate that both 2- and 12-biphenyl dibenzo[a,g]quinolizin-7-ium derivatives act as enhancers of FtsZ self-polymerization.<br /> (Copyright © 2012 Elsevier Ltd. All rights reserved.)
- Subjects :
- Anti-Bacterial Agents chemical synthesis
Anti-Bacterial Agents pharmacology
Bacterial Proteins antagonists & inhibitors
Bacterial Proteins metabolism
Berberine chemistry
Cytoskeletal Proteins antagonists & inhibitors
Cytoskeletal Proteins metabolism
Enterococcus faecalis drug effects
Microbial Sensitivity Tests
Quinolizines chemical synthesis
Quinolizines pharmacology
Staphylococcus aureus drug effects
Staphylococcus aureus metabolism
Structure-Activity Relationship
Anti-Bacterial Agents chemistry
Quinolizines chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1464-3405
- Volume :
- 22
- Issue :
- 22
- Database :
- MEDLINE
- Journal :
- Bioorganic & medicinal chemistry letters
- Publication Type :
- Academic Journal
- Accession number :
- 23058886
- Full Text :
- https://doi.org/10.1016/j.bmcl.2012.08.123