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Mss116p: a DEAD-box protein facilitates RNA folding.
- Source :
-
RNA biology [RNA Biol] 2013 Jan; Vol. 10 (1), pp. 71-82. Date of Electronic Publication: 2012 Oct 12. - Publication Year :
- 2013
-
Abstract
- RNA folding is an essential aspect underlying RNA-mediated cellular processes. Many RNAs, including large, multi-domain ribozymes, are capable of folding to the native, functional state without assistance of a protein cofactor in vitro. In the cell, trans-acting factors, such as proteins, are however known to modulate the structure and thus the fate of an RNA. DEAD-box proteins, including Mss116p, were recently found to assist folding of group I and group II introns in vitro and in vivo. The underlying mechanism(s) have been studied extensively to explore the contribution of ATP hydrolysis and duplex unwinding in helicase-stimulated intron splicing. Here we summarize the ongoing efforts to understand the novel role of DEAD-box proteins in RNA folding.
- Subjects :
- DEAD-box RNA Helicases chemistry
DEAD-box RNA Helicases genetics
Exons
Introns
Mitochondria genetics
Mitochondria metabolism
Mutation
Protein Binding
Protein Interaction Domains and Motifs physiology
RNA Splicing
RNA Stability
Yeasts
DEAD-box RNA Helicases metabolism
RNA chemistry
RNA metabolism
RNA Folding
Subjects
Details
- Language :
- English
- ISSN :
- 1555-8584
- Volume :
- 10
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- RNA biology
- Publication Type :
- Academic Journal
- Accession number :
- 23064153
- Full Text :
- https://doi.org/10.4161/rna.22492