Back to Search
Start Over
Highly active antiretroviral therapy and adverse birth outcomes among HIV-infected women in Botswana.
- Source :
-
The Journal of infectious diseases [J Infect Dis] 2012 Dec 01; Vol. 206 (11), pp. 1695-705. Date of Electronic Publication: 2012 Oct 12. - Publication Year :
- 2012
-
Abstract
- Background: It is unknown whether adverse birth outcomes are associated with maternal highly active antiretroviral therapy (HAART) in pregnancy, particularly in resource-limited settings.<br />Methods: We abstracted obstetrical records at 6 sites in Botswana for 24 months. Outcomes included stillbirths (SBs), preterm delivery (PTD), small for gestational age (SGA), and neonatal death (NND). Among human immunodeficiency virus (HIV)-infected women, comparisons were limited to HAART exposure status at conception, and those with similar opportunities for outcomes. Comparisons were adjusted for CD4(+) lymphocyte cell count.<br />Results: Of 33,148 women, 32,113 (97%) were tested for HIV, of whom 9504 (30%) were HIV infected. Maternal HIV was significantly associated with SB, PTD, SGA, and NND. Compared with all other HIV-infected women, those continuing HAART from before pregnancy had higher odds of PTD (adjusted odds ratio [AOR], 1.2; 95% confidence interval [CI], 1.1, 1.4), SGA (AOR, 1.8; 95% CI, 1.6, 2.1) and SB (AOR, 1.5; 95% CI, 1.2, 1.8). Among women initiating antiretroviral therapy in pregnancy, HAART use (vs zidovudine) was associated with higher odds of PTD (AOR, 1.4; 95% CI, 1.2, 1.8), SGA (AOR, 1.5; 95% CI, 1.2, 1.9), and SB (AOR, 2.5; 95% CI, 1.6, 3.9). Low CD4(+) was independently associated with SB and SGA, and maternal hypertension during pregnancy with PTD, SGA, and SB.<br />Conclusions: HAART receipt during pregnancy was associated with increased PTD, SGA, and SB.
- Subjects :
- Adult
Anti-HIV Agents administration & dosage
Birth Weight drug effects
Botswana epidemiology
Female
HIV Infections epidemiology
HIV Infections prevention & control
Humans
Infant Mortality
Infant, Newborn
Pregnancy
Retrospective Studies
Risk Factors
Time Factors
Young Adult
Anti-HIV Agents therapeutic use
Antiretroviral Therapy, Highly Active
HIV Infections drug therapy
Pregnancy Complications, Infectious drug therapy
Premature Birth
Stillbirth
Subjects
Details
- Language :
- English
- ISSN :
- 1537-6613
- Volume :
- 206
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- The Journal of infectious diseases
- Publication Type :
- Academic Journal
- Accession number :
- 23066160
- Full Text :
- https://doi.org/10.1093/infdis/jis553