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[Incidence of axillary recurrence after a negative sentinel lymph node result in early stages of breast cancer: a 5-year follow-up].
- Source :
-
Revista espanola de medicina nuclear e imagen molecular [Rev Esp Med Nucl Imagen Mol] 2012 Jul-Aug; Vol. 31 (4), pp. 173-7. Date of Electronic Publication: 2012 Jan 04. - Publication Year :
- 2012
-
Abstract
- Unlabelled: The sentinel lymph node (SLN) biopsy is currently the procedure of choice for axillary node staging in initial stages of breast cancer. The purpose of this study is to establish our false negative rate within a 5-year follow-up period in 258 patients with breast cancer staged with this procedure.<br />Methods: A retrospective study on 258 consecutive T1-T2<3 cm pN0 staged breast carcinomas treated from January 1, 2001 to December 31, 2005 was performed. The combined technique of isotope plus blue dye was used for detection. The subjects underwent a minimum follow-up of 5 years, mean 81 months, with an end of follow-up at December 31, 2010. Evidence of axillary recurrence, tumor recurrence in the breast and signs of disease progression or death were the events collected and analyzed.<br />Results: Of the 258 patients, 3 false negatives (1.1%) with axillary recurrence were detected at 10, 11 and 29 months of the surgery. This did not have a significant repercussion in the survival analysis on the contrary to the existence of breast recurrence or the appearance of distant metastasis in 4.7% and 6.2% patients, respectively. Global survival related with the cancer was 93.0 (240/258) and disease free survival was 89.1% (230/258).<br />Conclusion: The risk of developing axillary recurrence after a negative SLN without axillary node dissection is low enough to consider the SLN procedure to be the best approach for axilla staging in early breast cancer. This staging technique also makes it possible to achieve local disease control without diminishing the survival of the patients.<br /> (Copyright © 2011 Elsevier España, S.L. y SEMNIM. All rights reserved.)
- Subjects :
- Adult
Aged
Aged, 80 and over
Axilla
Breast Neoplasms surgery
Breast Neoplasms therapy
Carcinoma, Ductal, Breast diagnosis
Carcinoma, Ductal, Breast epidemiology
Carcinoma, Ductal, Breast surgery
Carcinoma, Lobular diagnosis
Carcinoma, Lobular epidemiology
Carcinoma, Lobular secondary
Carcinoma, Lobular surgery
Chemotherapy, Adjuvant
Combined Modality Therapy
Disease-Free Survival
Estrogens
False Negative Reactions
Female
Follow-Up Studies
Humans
Incidence
Lymph Node Excision
Mastectomy methods
Middle Aged
Neoplasm Staging
Neoplasms, Hormone-Dependent diagnosis
Neoplasms, Hormone-Dependent epidemiology
Neoplasms, Hormone-Dependent secondary
Neoplasms, Hormone-Dependent surgery
Progesterone
Prognosis
Radionuclide Imaging
Radiotherapy, Adjuvant
Retrospective Studies
Rosaniline Dyes
Sentinel Lymph Node Biopsy methods
Survival Analysis
Technetium Tc 99m Sulfur Colloid
Breast Neoplasms pathology
Carcinoma, Ductal, Breast secondary
Lymphatic Metastasis diagnostic imaging
Sentinel Lymph Node Biopsy statistics & numerical data
Subjects
Details
- Language :
- Spanish; Castilian
- ISSN :
- 2253-8070
- Volume :
- 31
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Revista espanola de medicina nuclear e imagen molecular
- Publication Type :
- Academic Journal
- Accession number :
- 23067685
- Full Text :
- https://doi.org/10.1016/j.remn.2011.11.006