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Regulation of mammalian cell differentiation by long non-coding RNAs.
- Source :
-
EMBO reports [EMBO Rep] 2012 Nov 06; Vol. 13 (11), pp. 971-83. Date of Electronic Publication: 2012 Oct 16. - Publication Year :
- 2012
-
Abstract
- Differentiation of specialized cell types from stem and progenitor cells is tightly regulated at several levels, both during development and during somatic tissue homeostasis. Many long non-coding RNAs have been recognized as an additional layer of regulation in the specification of cellular identities; these non-coding species can modulate gene-expression programmes in various biological contexts through diverse mechanisms at the transcriptional, translational or messenger RNA stability levels. Here, we summarize findings that implicate long non-coding RNAs in the control of mammalian cell differentiation. We focus on several representative differentiation systems and discuss how specific long non-coding RNAs contribute to the regulation of mammalian development.
- Subjects :
- Animals
Embryonic Stem Cells cytology
Embryonic Stem Cells metabolism
Gene Expression Regulation, Developmental
Genes, Homeobox
Humans
Induced Pluripotent Stem Cells cytology
Induced Pluripotent Stem Cells metabolism
Mammals
RNA, Long Noncoding classification
RNA, Long Noncoding genetics
Cell Differentiation
RNA, Long Noncoding metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1469-3178
- Volume :
- 13
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- EMBO reports
- Publication Type :
- Academic Journal
- Accession number :
- 23070366
- Full Text :
- https://doi.org/10.1038/embor.2012.145