Back to Search
Start Over
Novel inhibitors of Staphylococcus aureus virulence gene expression and biofilm formation.
- Source :
-
PloS one [PLoS One] 2012; Vol. 7 (10), pp. e47255. Date of Electronic Publication: 2012 Oct 15. - Publication Year :
- 2012
-
Abstract
- Staphylococcus aureus is a major human pathogen and one of the more prominent pathogens causing biofilm related infections in clinic. Antibiotic resistance in S. aureus such as methicillin resistance is approaching an epidemic level. Antibiotic resistance is widespread among major human pathogens and poses a serious problem for public health. Conventional antibiotics are either bacteriostatic or bacteriocidal, leading to strong selection for antibiotic resistant pathogens. An alternative approach of inhibiting pathogen virulence without inhibiting bacterial growth may minimize the selection pressure for resistance. In previous studies, we identified a chemical series of low molecular weight compounds capable of inhibiting group A streptococcus virulence following this alternative anti-microbial approach. In the current study, we demonstrated that two analogs of this class of novel anti-virulence compounds also inhibited virulence gene expression of S. aureus and exhibited an inhibitory effect on S. aureus biofilm formation. This class of anti-virulence compounds could be a starting point for development of novel anti-microbial agents against S. aureus.
- Subjects :
- Anti-Bacterial Agents chemical synthesis
Anti-Bacterial Agents pharmacology
Humans
Methicillin Resistance genetics
Methicillin-Resistant Staphylococcus aureus genetics
Methicillin-Resistant Staphylococcus aureus pathogenicity
Microbial Sensitivity Tests
Quinazolines chemical synthesis
Small Molecule Libraries
Streptokinase genetics
Biofilms drug effects
Biofilms growth & development
Gene Expression Regulation, Bacterial drug effects
Methicillin-Resistant Staphylococcus aureus drug effects
Quinazolines pharmacology
Streptokinase antagonists & inhibitors
Subjects
Details
- Language :
- English
- ISSN :
- 1932-6203
- Volume :
- 7
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- PloS one
- Publication Type :
- Academic Journal
- Accession number :
- 23077578
- Full Text :
- https://doi.org/10.1371/journal.pone.0047255