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Association of subclinical atherosclerosis with lipid levels amongst antiretroviral-treated and untreated HIV-infected women in the Women's Interagency HIV study.
- Source :
-
Atherosclerosis [Atherosclerosis] 2012 Dec; Vol. 225 (2), pp. 408-11. Date of Electronic Publication: 2012 Oct 05. - Publication Year :
- 2012
-
Abstract
- Objective: We examined serum lipids in association with carotid artery intima-media thickness (CIMT) in HIV-infected and HIV-uninfected women.<br />Methods: In 2003-4, among 1827 Women's Interagency HIV Study participants, we measured CIMT and lipids (high-density lipoprotein cholesterol (HDL-c), low-density lipoprotein cholesterol (LDL-c), total cholesterol (TC), non-HDL-c). A subset of 520 treated HIV-infected women had pre-1997 lipid measures. We used multivariable linear regression to examine associations between lipids and CIMT.<br />Results: In HIV-uninfected women, higher TC, LDL-c and non-HDL-c were associated with increased CIMT. Among HIV-infected women, associations of lipids with CIMT were observed in treated but not untreated women. Among the HIV-infected women treated in 2003-4, CIMT was associated both with lipids measured a decade earlier in infection, and with late lipid measurements.<br />Conclusion: Among HIV-infected women, hyperlipidemia is most strongly associated with subclinical atherosclerosis in treated women. Among treated women, the association appeared strongest early in the disease course.<br /> (Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.)
- Subjects :
- Adult
Antiretroviral Therapy, Highly Active
Asymptomatic Diseases
Atherosclerosis diagnosis
Atherosclerosis ethnology
Biomarkers blood
Carotid Intima-Media Thickness
Cholesterol, HDL blood
Cholesterol, LDL blood
Disease Progression
Female
HIV Infections blood
HIV Infections diagnosis
HIV Infections ethnology
Humans
Hyperlipidemias diagnosis
Hyperlipidemias ethnology
Linear Models
Middle Aged
Multivariate Analysis
Risk Factors
Time Factors
United States epidemiology
Anti-Retroviral Agents therapeutic use
Atherosclerosis blood
Cholesterol blood
HIV Infections drug therapy
Hyperlipidemias blood
Subjects
Details
- Language :
- English
- ISSN :
- 1879-1484
- Volume :
- 225
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Atherosclerosis
- Publication Type :
- Academic Journal
- Accession number :
- 23089369
- Full Text :
- https://doi.org/10.1016/j.atherosclerosis.2012.09.035