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Chemical constituents of Arisaema franchetianum tubers.
- Source :
-
Journal of Asian natural products research [J Asian Nat Prod Res] 2013; Vol. 15 (1), pp. 71-7. Date of Electronic Publication: 2012 Oct 29. - Publication Year :
- 2013
-
Abstract
- A novel pyrrolidine alkaloid, (2R*,3S*,5S*)-N,2-dimethyl-3-hydroxy-5-(10-phenyldecyl)pyrrolidine (1), and 17 known compounds were isolated from Arisaema franchetianum Engl. (Araceae) tubers. The 17 compounds were bergenin (2), emodin (3), caffeic acid (4), nobiletin (5), 3-O-β-d-galactopyranosyl-hederagenin 28-O-β-d-xylopyranosyl(1 → 6)-β-d-galactopyranosyl ester (6), coniferin (7), qingyangshengenin (8), methylconiferin (9), syringaresinol 4'-O-β-d-glucopyranoside (10), gagaminine (11), perlolyrine (12), (S)-1-(1'-hydroxyethyl)-β-carboline (13), 1-(β-carboline-1-yl)-3,4,5-trihydroxy-1-pentanone (14), 1-methoxycarbonyl-β-carboline (15), indolo[2,3-α]carbazole (16), 4-hydroxycinnamic acid methyl ester (17), and methyl 4-[2-hydroxy-2-(4-hydroxy-3-methoxyphenyl)-1-(hydroxymethyl)ethyl] ferulate (18). The inhibitory activities of compound 1 and its N-methyl derivative (1a) against porcine respiratory and reproductive syndrome virus (PRRSV), human leukemic K562 cells, and human breast cancer MCF-7 cells were evaluated. Compounds 1 [50% inhibited concentration (IC(50)) = 12.5 ± 0.6 μM] and 1a (IC(50) = 15.7 ± 0.9 μM) were cytotoxic against K562 cells. Compound 1a also had a weak effect on PRRSV with an IC(50) value of 31.9 ± 6.0 μM [selectivity index (SI) = 18.7].
- Subjects :
- Alkaloids chemistry
Alkaloids pharmacology
Animals
Antineoplastic Agents, Phytogenic chemistry
Antineoplastic Agents, Phytogenic pharmacology
Antiviral Agents chemistry
Antiviral Agents pharmacology
Drug Screening Assays, Antitumor
Female
Glucosides chemistry
Glucosides isolation & purification
Glycosides chemistry
Glycosides isolation & purification
Glycosides pharmacology
Humans
Inhibitory Concentration 50
K562 Cells
Lignans chemistry
Lignans isolation & purification
MCF-7 Cells
Molecular Structure
Oleanolic Acid analogs & derivatives
Oleanolic Acid chemistry
Oleanolic Acid isolation & purification
Plant Tubers chemistry
Porcine respiratory and reproductive syndrome virus drug effects
Pyrrolidines chemistry
Pyrrolidines pharmacology
Swine
Alkaloids isolation & purification
Antineoplastic Agents, Phytogenic isolation & purification
Antiviral Agents isolation & purification
Arisaema chemistry
Pyrrolidines isolation & purification
Subjects
Details
- Language :
- English
- ISSN :
- 1477-2213
- Volume :
- 15
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Journal of Asian natural products research
- Publication Type :
- Academic Journal
- Accession number :
- 23106482
- Full Text :
- https://doi.org/10.1080/10286020.2012.723202