Back to Search
Start Over
Modulation of neuropathic-pain-related behaviour by the spinal endocannabinoid/endovanilloid system.
- Source :
-
Philosophical transactions of the Royal Society of London. Series B, Biological sciences [Philos Trans R Soc Lond B Biol Sci] 2012 Dec 05; Vol. 367 (1607), pp. 3286-99. - Publication Year :
- 2012
-
Abstract
- Neuropathic pain refers to chronic pain that results from injury to the nervous system. The mechanisms involved in neuropathic pain are complex and involve both peripheral and central phenomena. Although numerous pharmacological agents are available for the treatment of neuropathic pain, definitive drug therapy has remained elusive. Recent drug discovery efforts have identified an original neurobiological approach to the pathophysiology of neuropathic pain. The development of innovative pharmacological strategies has led to the identification of new promising pharmacological targets, including glutamate antagonists, microglia inhibitors and, interestingly, endogenous ligands of cannabinoids and the transient receptor potential vanilloid type 1 (TRPV1). Endocannabinoids (ECs), endovanilloids and the enzymes that regulate their metabolism represent promising pharmacological targets for the development of a successful pain treatment. This review is an update of the relationship between cannabinoid receptors (CB1) and TRPV1 channels and their possible implications for neuropathic pain. The data are focused on endogenous spinal mechanisms of pain control by anandamide, and the current and emerging pharmacotherapeutic approaches that benefit from the pharmacological modulation of spinal EC and/or endovanilloid systems under chronic pain conditions will be discussed.
- Subjects :
- Amides
Amidohydrolases metabolism
Animals
Arachidonic Acid metabolism
Arachidonic Acids pharmacology
Benzamides pharmacology
Carbamates pharmacology
Endocannabinoids pharmacology
Enzyme Inhibitors pharmacology
Ethanolamines metabolism
Glycerides metabolism
Humans
Microglia drug effects
Microglia metabolism
Neuralgia drug therapy
Palmitic Acids metabolism
Peripheral Nerve Injuries drug therapy
Peripheral Nerve Injuries physiopathology
Polyunsaturated Alkamides pharmacology
Spinal Cord Injuries drug therapy
Spinal Cord Injuries physiopathology
TRPV Cation Channels metabolism
Amidohydrolases antagonists & inhibitors
Arachidonic Acids metabolism
Behavior drug effects
Endocannabinoids metabolism
Neuralgia physiopathology
Neuralgia psychology
Polyunsaturated Alkamides metabolism
Receptor, Cannabinoid, CB1 metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1471-2970
- Volume :
- 367
- Issue :
- 1607
- Database :
- MEDLINE
- Journal :
- Philosophical transactions of the Royal Society of London. Series B, Biological sciences
- Publication Type :
- Academic Journal
- Accession number :
- 23108547
- Full Text :
- https://doi.org/10.1098/rstb.2011.0392