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A bilateral primary yolk sac tumor of the lung associated with chromosome 3 polysomy: understanding the Oct 3/4 and Sox 2 interaction.
- Source :
-
Cancer biology & therapy [Cancer Biol Ther] 2013 Jan; Vol. 14 (1), pp. 1-4. Date of Electronic Publication: 2012 Oct 31. - Publication Year :
- 2013
-
Abstract
- Extragonadal germ cell tumors (EGCTs) in the lung are extremely rare and their pathogenesis is poorly understood. We report a case in a 48-year-old female which was very aggressive and stained positive for primoridial germ cell markers. Interestingly, there was chromosome 3 polysomy noted. To our knowledge this is the first chromosomal aberration noted in a primary germ cell tumor of the lung.
- Subjects :
- Antineoplastic Combined Chemotherapy Protocols therapeutic use
Chromosomes, Human, Pair 3
Cisplatin administration & dosage
Drug Resistance, Neoplasm
Endodermal Sinus Tumor drug therapy
Endodermal Sinus Tumor genetics
Etoposide administration & dosage
Fatal Outcome
Female
Humans
Lung Neoplasms drug therapy
Lung Neoplasms genetics
Octamer Transcription Factor-3 genetics
Radiography
Aneuploidy
Endodermal Sinus Tumor diagnostic imaging
Lung Neoplasms diagnostic imaging
Octamer Transcription Factor-3 metabolism
SOXB1 Transcription Factors genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1555-8576
- Volume :
- 14
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Cancer biology & therapy
- Publication Type :
- Report
- Accession number :
- 23114647
- Full Text :
- https://doi.org/10.4161/cbt.22624