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Lymphoma risk and occupational exposure to pesticides: results of the Epilymph study.
- Source :
-
Occupational and environmental medicine [Occup Environ Med] 2013 Feb; Vol. 70 (2), pp. 91-8. Date of Electronic Publication: 2012 Nov 01. - Publication Year :
- 2013
-
Abstract
- Objectives: We investigated the role of occupational exposure to specific groups of agrochemicals in the aetiology of lymphoma overall, B cell lymphoma and its most prevalent subtypes.<br />Methods: In 1998-2003, 2348 incident lymphoma cases and 2462 controls were recruited to the EPILYMPH case-control study in six European countries. A detailed occupational history was collected in cases and controls. Job modules were applied for farm work including specific questions on type of crop, farm size, pests being treated, type and schedule of pesticide use. In each study centre, industrial hygienists and occupational experts assessed exposure to specific groups of pesticides and individual compounds with the aid of agronomists. We calculated the OR and its 95% CI associated with lymphoma and the most prevalent lymphoma subtypes with unconditional logistic regression, adjusting for age, gender, education and centre.<br />Results: Risk of lymphoma overall, and B cell lymphoma was not elevated, and risk of chronic lymphocytic leukaemia (CLL) was elevated amongst those ever exposed to inorganic (OR=1.6, 95% CI 1.0 to 2.5) and organic pesticides (OR=1.5, 95% CI 1.0 to 2.1). CLL risk was highest amongst those ever exposed to organophosphates (OR=2.7, 95% CI 1.2 to 6.0). Restricting the analysis to subjects most likely exposed, no association was observed between pesticide use and risk of B cell lymphoma.<br />Conclusions: Our results provide limited support to the hypothesis of an increase in risk of specific lymphoma subtypes associated with exposure to pesticides.
- Subjects :
- Adult
Case-Control Studies
Europe epidemiology
Female
Humans
Leukemia, Lymphocytic, Chronic, B-Cell chemically induced
Leukemia, Lymphocytic, Chronic, B-Cell epidemiology
Lymphoma epidemiology
Lymphoma, B-Cell chemically induced
Lymphoma, B-Cell epidemiology
Male
Occupational Exposure analysis
Risk Factors
Lymphoma chemically induced
Occupational Exposure adverse effects
Pesticides toxicity
Subjects
Details
- Language :
- English
- ISSN :
- 1470-7926
- Volume :
- 70
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Occupational and environmental medicine
- Publication Type :
- Academic Journal
- Accession number :
- 23117219
- Full Text :
- https://doi.org/10.1136/oemed-2012-100845