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Duloxetine and pregabalin for pain management in multiple rheumatic diseases associated with fibromyalgia.
Duloxetine and pregabalin for pain management in multiple rheumatic diseases associated with fibromyalgia.
- Source :
-
Pain practice : the official journal of World Institute of Pain [Pain Pract] 2013 Nov; Vol. 13 (8), pp. 657-62. Date of Electronic Publication: 2012 Nov 05. - Publication Year :
- 2013
-
Abstract
- The fibromyalgia syndrome (FMS) is characterized by chronic and widespread musculoskeletal pain and soreness accompanied by sleep disorders, chronic fatigue and affective disorders. FMS is often associated with other forms of immuno-rheumatic diseases. Although FMS pathophysiology is still not fully understood, a number of neuroendocrine, neurotransmission and neurosensitive disorders might generate a mechanism for the elicitation of pain by "central sensitization," which is common to many other painful conditions. The present case describes the success of a therapeutic scheme, which associates two different pharmacological classes, anticonvulsants and new-generation antidepressants, when FMS complicates a rare pathology called Cogan's syndrome. The association of two drugs might noticeably affect the molecular mechanisms of difficult pain, thus solving painful conditions of multifactorial origin.<br /> (© 2013 The Authors Pain Practice © 2012 World Institute of Pain.)
- Subjects :
- Comorbidity
Duloxetine Hydrochloride
Female
Fibromyalgia epidemiology
Fibromyalgia physiopathology
Humans
Middle Aged
Pregabalin
Rheumatic Diseases epidemiology
Rheumatic Diseases physiopathology
gamma-Aminobutyric Acid therapeutic use
Analgesics therapeutic use
Fibromyalgia drug therapy
Rheumatic Diseases drug therapy
Thiophenes therapeutic use
gamma-Aminobutyric Acid analogs & derivatives
Subjects
Details
- Language :
- English
- ISSN :
- 1533-2500
- Volume :
- 13
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Pain practice : the official journal of World Institute of Pain
- Publication Type :
- Academic Journal
- Accession number :
- 23126475
- Full Text :
- https://doi.org/10.1111/papr.12009