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Duloxetine and pregabalin for pain management in multiple rheumatic diseases associated with fibromyalgia.

Duloxetine and pregabalin for pain management in multiple rheumatic diseases associated with fibromyalgia.

Authors :
Angeletti C
Guetti C
Piroli A
Angeletti PM
Paladini A
Ciccozzi A
Marinangeli F
Varrassi G
Source :
Pain practice : the official journal of World Institute of Pain [Pain Pract] 2013 Nov; Vol. 13 (8), pp. 657-62. Date of Electronic Publication: 2012 Nov 05.
Publication Year :
2013

Abstract

The fibromyalgia syndrome (FMS) is characterized by chronic and widespread musculoskeletal pain and soreness accompanied by sleep disorders, chronic fatigue and affective disorders. FMS is often associated with other forms of immuno-rheumatic diseases. Although FMS pathophysiology is still not fully understood, a number of neuroendocrine, neurotransmission and neurosensitive disorders might generate a mechanism for the elicitation of pain by "central sensitization," which is common to many other painful conditions. The present case describes the success of a therapeutic scheme, which associates two different pharmacological classes, anticonvulsants and new-generation antidepressants, when FMS complicates a rare pathology called Cogan's syndrome. The association of two drugs might noticeably affect the molecular mechanisms of difficult pain, thus solving painful conditions of multifactorial origin.<br /> (© 2013 The Authors Pain Practice © 2012 World Institute of Pain.)

Details

Language :
English
ISSN :
1533-2500
Volume :
13
Issue :
8
Database :
MEDLINE
Journal :
Pain practice : the official journal of World Institute of Pain
Publication Type :
Academic Journal
Accession number :
23126475
Full Text :
https://doi.org/10.1111/papr.12009