Role of fatty acid-based functional lipidomics in the development of molecular diagnostic tools.

Lipids are molecules with different structures which have the feature of water insolubility in common. They have very important biological roles within structural, functional and signaling activities that have recently received renewed attention from life science research. Lipidomics considers the structural and functional roles played by lipids, but also their in vivo changes due to metabolic or degradation pathways, as well as their biological consequences. In this context, the dynamic vision of phospholipid metabolism and, in particular, fatty acid transformations combine with nutritional aspects and health consequences, providing important information for molecular medicine. Fatty acid-based functional lipidomics can be successfully applied to the follow-up of human lipid profiles under normal and pathological conditions, and this review provides several examples of this powerful molecular diagnostic tool, which is expected to have a strong influence on biomedical research in the 21st century.