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[Intravenous arginine vasopressin for two pediatric cases of pulmonary hypertension after congenital heart surgery].
- Source :
-
Masui. The Japanese journal of anesthesiology [Masui] 2012 Oct; Vol. 61 (10), pp. 1112-6. - Publication Year :
- 2012
-
Abstract
- We experienced two pediatric cases of severe pulmonary hypertension after congenital heart surgery. It was difficult to wean two cases from cardiopulmonary bypass for systemic hypotension concomitant with pulmonary hypertension reflactory to conventional therapy, including administration of adrenaline, nitroglycerin, milrinone, and/or inhalation of nitric oxide. In order to increase systemic arterial blood pressure and improve severe right heart failure, we administered arginine vasopressin (AVP) intravenously, which is a potent vasoconstrictor via V1 receptor. The dose of AVP was 0.0002 unit x kg(-1) x min(-1). After administration of AVP, systemic arterial pressure increased markedly and pulmonary arterial pressure decreased slightly, and we succeeded in weaning the patients from cardiopulmonary bypass. No adverse effect with AVP was found. In conclusion, administration of AVP is a therapeutic option for treating systemic hypotension concomitant with severe pulmonary hypertension in pediatric congenital heart surgery.
- Subjects :
- Female
Humans
Hypotension drug therapy
Hypotension etiology
Infant
Infusions, Intravenous
Male
Severity of Illness Index
Treatment Outcome
Arginine Vasopressin administration & dosage
Cardiopulmonary Bypass
Heart Defects, Congenital complications
Heart Defects, Congenital surgery
Hypertension, Pulmonary complications
Hypertension, Pulmonary drug therapy
Vasoconstrictor Agents administration & dosage
Subjects
Details
- Language :
- Japanese
- ISSN :
- 0021-4892
- Volume :
- 61
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Masui. The Japanese journal of anesthesiology
- Publication Type :
- Academic Journal
- Accession number :
- 23157099