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[Analysis of recurrence patterns after curative resection of stage IIIA-N2 non-small cell lung cancer].
- Source :
-
Zhonghua yi xue za zhi [Zhonghua Yi Xue Za Zhi] 2012 Sep 04; Vol. 92 (33), pp. 2314-8. - Publication Year :
- 2012
-
Abstract
- Objective: To explore the postoperative recurrence patterns in the patients undergoing potentially curative resection of stage IIIA-N2 non-small cell lung cancer (NSCLC).<br />Methods: A total of 63 patients underwent curative operation from September 2004 to December 2008 at Peking University First Hospital and were pathologically diagnosed as stage IIIA-N2 NSCLC. Their clinical data were retrospectively reviewed. The follow-ups were conducted to detect the recurrent lesions. The recurrence rates at Year 2-3 were calculated by the Kaplan-Meier method while the Cox proportional hazard model was used to assess the risk factors associated with recurrence.<br />Results: The 2 and 3-year recurrence rate was 46.6% and 57.3% respectively. Only one patient experienced local failure. However, the predominant recurrence pattern was distant failure (27/28). As demonstrated by the univariate Cox regression analysis, 4 significant factors associated with recurrence and the arm of lymphatic or vascular invasion (LVI), number of positive N2 station > 1, number of positive node > 3 and involvement of subcarinal lymph nodes were found to increase the risks of failure (P < 0.05).<br />Conclusion: Distant failure is the predominant pattern of postoperative recurrence in the patients of stage IIIA-N2 NSCLC. In addition to LVI, the level of positive N2 station, the number of positive N2 node and the involvement of subcarinal lymph nodes are associated with the postoperative risk of recurrence.
- Subjects :
- Adult
Aged
Carcinoma, Non-Small-Cell Lung surgery
Female
Humans
Kaplan-Meier Estimate
Lung Neoplasms surgery
Lymphatic Metastasis
Male
Mediastinum pathology
Middle Aged
Neoplasm Recurrence, Local
Neoplasm Staging
Postoperative Period
Proportional Hazards Models
Retrospective Studies
Risk Factors
Carcinoma, Non-Small-Cell Lung pathology
Lung Neoplasms pathology
Lymph Nodes pathology
Subjects
Details
- Language :
- Chinese
- ISSN :
- 0376-2491
- Volume :
- 92
- Issue :
- 33
- Database :
- MEDLINE
- Journal :
- Zhonghua yi xue za zhi
- Publication Type :
- Academic Journal
- Accession number :
- 23158558