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Pulmonary alveolar proteinosis and disseminated atypical mycobacteriosis in a patient with busulfan lung.
- Source :
-
Acta pathologica japonica [Acta Pathol Jpn] 1990 Jan; Vol. 40 (1), pp. 63-6. - Publication Year :
- 1990
-
Abstract
- A 32-year-old Japanese man with chronic granulocytic leukemia died of respiratory failure. Autopsy revealed alveolar proteinosis and pulmonary fibrosis, complicated by disseminated atypical mycobacteriosis. Epithelial hyperplasia caused by busulfan therapy was probably responsible for the induction of excessive surfactant production, resulting in alveolar proteinosis, and the immunosuppressive state due to chronic granulocytic leukemia was probably related to the induction of disseminated atypical mycobacteriosis.
- Subjects :
- Adult
Autopsy
Busulfan therapeutic use
Humans
Leukemia, Myelogenous, Chronic, BCR-ABL Positive drug therapy
Lung drug effects
Lung metabolism
Lung pathology
Lung Diseases chemically induced
Male
Mycobacterium Infections, Nontuberculous pathology
Opportunistic Infections etiology
Opportunistic Infections metabolism
Opportunistic Infections pathology
Pulmonary Alveolar Proteinosis metabolism
Pulmonary Alveolar Proteinosis pathology
Busulfan adverse effects
Lung Diseases complications
Mycobacterium Infections complications
Mycobacterium Infections, Nontuberculous complications
Pulmonary Alveolar Proteinosis complications
Subjects
Details
- Language :
- English
- ISSN :
- 0001-6632
- Volume :
- 40
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Acta pathologica japonica
- Publication Type :
- Academic Journal
- Accession number :
- 2316373
- Full Text :
- https://doi.org/10.1111/j.1440-1827.1990.tb01530.x