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Protection against West Nile virus infection in mice after inoculation with type I interferon-inducing RNA transcripts.
- Source :
-
PloS one [PLoS One] 2012; Vol. 7 (11), pp. e49494. Date of Electronic Publication: 2012 Nov 14. - Publication Year :
- 2012
-
Abstract
- West Nile virus (WNV) is a neurovirulent single stranded RNA mosquito-borne flavivirus, whose main natural hosts are birds, but it also infects humans and horses. Nowadays, no human vaccine is commercially available and clinical treatment is only supportive. Recently, it has been shown that RNA transcripts, mimicking structural domains in the non-coding regions (NCRs) of the foot-and mouth disease virus (FMDV) induce a potent IFN response and antiviral activity in transfected cultured cells, and also reduced mice susceptibility to FMDV. By using different transcripts combinations, administration schedules, and infecting routes and doses, we have demonstrated that these FMDV RNA transcripts protect suckling and adult mice against lethal challenge with WNV. The protective activity induced by the transcripts was systemic and dependent on the infection route and dose. These results confirm the antiviral potential of these synthetic RNAs for fighting viruses of different families relevant for human and animal health.
- Subjects :
- Animals
Gene Expression Regulation, Viral
Immunity, Innate
Interferon Type I immunology
Mice
RNA, Untranslated genetics
West Nile Fever mortality
Interferon Type I blood
RNA, Viral genetics
West Nile Fever immunology
West Nile Fever prevention & control
West Nile virus genetics
West Nile virus immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1932-6203
- Volume :
- 7
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- PloS one
- Publication Type :
- Academic Journal
- Accession number :
- 23166685
- Full Text :
- https://doi.org/10.1371/journal.pone.0049494