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Effects of rectal administration of taurocholic acid on glucagon-like peptide-1 and peptide YY secretion in healthy humans.
- Source :
-
Diabetes, obesity & metabolism [Diabetes Obes Metab] 2013 May; Vol. 15 (5), pp. 474-7. Date of Electronic Publication: 2012 Dec 17. - Publication Year :
- 2013
-
Abstract
- Glucagon-like peptide-1 (GLP-1) and peptide YY (PYY), secreted by enteroendocrine L-cells located most densely in the colon and rectum, are of fundamental importance in blood glucose and appetite regulation. In animal models, colonic administration of bile acids can stimulate GLP-1 and PYY by TGR5 receptor activation. We evaluated the effects of taurocholic acid (TCA), administered as an enema, on plasma GLP-1 and PYY, as well as gastrointestinal sensations in 10 healthy male subjects, and observed that rectal administration of TCA promptly stimulated secretion of both GLP-1 and PYY, and increased fullness, in a dose-dependent manner. These observations confirm that topical application of bile acids to the distal gut may have potential for the management of type 2 diabetes and obesity.<br /> (© 2012 Blackwell Publishing Ltd.)
- Subjects :
- Administration, Rectal
Adult
Appetite Regulation drug effects
Blood Glucose drug effects
Blood Glucose metabolism
Body Mass Index
Cholagogues and Choleretics administration & dosage
Cholagogues and Choleretics pharmacology
Diabetes Mellitus, Type 2 drug therapy
Diabetes Mellitus, Type 2 physiopathology
Enema
Humans
Male
Obesity drug therapy
Obesity physiopathology
Treatment Outcome
Glucagon-Like Peptide 1 drug effects
Glucagon-Like Peptide 1 metabolism
Peptide YY drug effects
Peptide YY metabolism
Taurocholic Acid administration & dosage
Taurocholic Acid pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1463-1326
- Volume :
- 15
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Diabetes, obesity & metabolism
- Publication Type :
- Academic Journal
- Accession number :
- 23181598
- Full Text :
- https://doi.org/10.1111/dom.12043