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Prognostic factors and clinical features in patients with leptominengeal metastases from breast cancer: a single center experience.
Prognostic factors and clinical features in patients with leptominengeal metastases from breast cancer: a single center experience.
- Source :
-
Journal of chemotherapy (Florence, Italy) [J Chemother] 2012 Oct; Vol. 24 (5), pp. 279-84. - Publication Year :
- 2012
-
Abstract
- Background: Meningeal carcinomatosis (MC) is a rare complication in breast cancer (BC) with no efficient modality of treatment yet found; overall survival (OS) generally did not exceed six months. We reviewed the experience of the University of Florence focusing on prognostic factors and MC survival.<br />Patients and Methods: We analyzed 33 patients treated for MC from BC between 2002 and 2010.<br />Results: Mean OS from MC diagnosis was 4.9 months. At survival analysis clinical stage emerged as the only statistical significant parameter (P = 0.009) among BC diagnosis features. Among MC diagnosis parameters, more than three metastases at diagnosis (P = 0.037), multimodality treatment (P = 0.014) and poor performance status (P = 0.003) reached the statistical significance. At multivariate analysis only performance status at MC diagnosis maintained the statistical significance (P = 0.0047; HR: 3.34; CI 95% 1.45-7.73).<br />Conclusions: Our experience confirms that performance status is probably the most important prognostic factor in these patients. Multimodality approach is probably the best option.
- Subjects :
- Adult
Aged
Breast Neoplasms diagnosis
Female
Humans
Italy epidemiology
Kaplan-Meier Estimate
Karnofsky Performance Status
Meningeal Carcinomatosis diagnosis
Middle Aged
Prognosis
Breast Neoplasms mortality
Breast Neoplasms pathology
Meningeal Carcinomatosis mortality
Meningeal Carcinomatosis secondary
Subjects
Details
- Language :
- English
- ISSN :
- 1973-9478
- Volume :
- 24
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Journal of chemotherapy (Florence, Italy)
- Publication Type :
- Academic Journal
- Accession number :
- 23182047
- Full Text :
- https://doi.org/10.1179/1973947812Y.0000000034