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Prognostic factors and clinical features in patients with leptominengeal metastases from breast cancer: a single center experience.

Prognostic factors and clinical features in patients with leptominengeal metastases from breast cancer: a single center experience.

Authors :
Meattini I
Livi L
Saieva C
Franceschini D
Marrazzo L
Greto D
Scotti V
Scoccianti S
Paiar F
Bordi L
Nori J
Sanchez L
Orzalesi L
Bianchi S
Biti G
Source :
Journal of chemotherapy (Florence, Italy) [J Chemother] 2012 Oct; Vol. 24 (5), pp. 279-84.
Publication Year :
2012

Abstract

Background: Meningeal carcinomatosis (MC) is a rare complication in breast cancer (BC) with no efficient modality of treatment yet found; overall survival (OS) generally did not exceed six months. We reviewed the experience of the University of Florence focusing on prognostic factors and MC survival.<br />Patients and Methods: We analyzed 33 patients treated for MC from BC between 2002 and 2010.<br />Results: Mean OS from MC diagnosis was 4.9 months. At survival analysis clinical stage emerged as the only statistical significant parameter (P = 0.009) among BC diagnosis features. Among MC diagnosis parameters, more than three metastases at diagnosis (P = 0.037), multimodality treatment (P = 0.014) and poor performance status (P = 0.003) reached the statistical significance. At multivariate analysis only performance status at MC diagnosis maintained the statistical significance (P = 0.0047; HR: 3.34; CI 95% 1.45-7.73).<br />Conclusions: Our experience confirms that performance status is probably the most important prognostic factor in these patients. Multimodality approach is probably the best option.

Details

Language :
English
ISSN :
1973-9478
Volume :
24
Issue :
5
Database :
MEDLINE
Journal :
Journal of chemotherapy (Florence, Italy)
Publication Type :
Academic Journal
Accession number :
23182047
Full Text :
https://doi.org/10.1179/1973947812Y.0000000034