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Simian T-cell lymphotropic virus type I alters the proviral load and biodistribution of simian retrovirus type 2 in co-infected macaques, supporting advancement of immunosuppressive pathology.
- Source :
-
The Journal of general virology [J Gen Virol] 2013 Mar; Vol. 94 (Pt 3), pp. 623-633. Date of Electronic Publication: 2012 Nov 28. - Publication Year :
- 2013
-
Abstract
- The infection dynamics and pathology of a retrovirus may be altered by one or more additional viruses. To investigate this further, this study characterized proviral load, biodistribution and the immune response in Macaca fascicularis naturally infected with combinations of simian retrovirus type 2 (SRV-2) and simian T-cell lymphotropic virus type I (STLV-I). As the mesenteric lymph node (MLN) and the spleen have been implicated previously in response to retroviral infection, the morphology and immunopathology of these tissues were assessed. The data revealed a significant change in SRV-2 biodistribution in macaques infected with STLV-I. Pathological changes were greater in the MLN and spleen of STLV-I-infected and co-infected macaques compared with the other groups. Immune-cell populations in co-infected macaque spleens were increased and there was an atypical distribution of B-cells. These findings suggest that the infection dynamics of each virus in a co-infected individual may be affected to a different extent and that STLV-I appears to be responsible for enhancing the biodistribution and associated pathological changes in SRV-2 in macaques.
- Subjects :
- Animals
Deltaretrovirus Infections immunology
Deltaretrovirus Infections virology
Gastrointestinal Tract virology
Kidney virology
Lymphoid Tissue virology
Simian Acquired Immunodeficiency Syndrome immunology
Viral Load
Deltaretrovirus Infections veterinary
Macaca fascicularis
Mason-Pfizer monkey virus physiology
Simian Acquired Immunodeficiency Syndrome virology
Simian T-lymphotropic virus 1 physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1465-2099
- Volume :
- 94
- Issue :
- Pt 3
- Database :
- MEDLINE
- Journal :
- The Journal of general virology
- Publication Type :
- Academic Journal
- Accession number :
- 23197576
- Full Text :
- https://doi.org/10.1099/vir.0.046078-0