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Association of the interleukin 1 beta gene and brain spontaneous activity in amnestic mild cognitive impairment.
- Source :
-
Journal of neuroinflammation [J Neuroinflammation] 2012 Dec 01; Vol. 9, pp. 263. Date of Electronic Publication: 2012 Dec 01. - Publication Year :
- 2012
-
Abstract
- Purpose: The inflammatory response has been associated with the pathogenesis of Alzheimer's disease (AD). The purpose of this study is to determine whether the rs1143627 polymorphism of the interleukin-1 beta (IL-1β) gene moderates functional magnetic resonance imaging (fMRI)-measured brain regional activity in amnestic mild cognitive impairment (aMCI).<br />Methods: Eighty older participants (47 with aMCI and 33 healthy controls) were recruited for this study. All of the participants were genotyped for variant rs1143627 in the IL1B gene and were scanned using resting-state fMRI. Brain activity was assessed by amplitude of low-frequency fluctuation (ALFF).<br />Results: aMCI patients had abnormal ALFF in many brain regions, including decreases in the inferior frontal gyrus, the superior temporal lobe and the middle temporal lobe, and increases in the occipital cortex (calcarine), parietal cortex (Pcu) and cerebellar cortex. The regions associated with an interaction of group X genotypes of rs1143627 C/T were the parietal cortex (left Pcu), frontal cortex (left superior, middle, and medial gyrus, right anterior cingulum), occipital cortex (left middle lobe, left cuneus) and the bilateral posterior lobes of the cerebellum. Regarding the behavioral significance, there were significant correlations between ALFF in different regions of the brain and with the cognitive scores of each genotype group.<br />Conclusions: The present study provided evidence that aMCI patients had abnormal ALFF in many brain regions. Specifically, the rs1143627 C/T polymorphism of the IL1B gene may modulate regional spontaneous brain activity in aMCI patients.
- Subjects :
- Aged
Brain Mapping
Case-Control Studies
China
Cognitive Dysfunction ethnology
Female
Gene Frequency
Genotype
Humans
Image Processing, Computer-Assisted
Magnetic Resonance Imaging
Male
Middle Aged
Neuropsychological Tests
Statistics as Topic
Brain pathology
Cognitive Dysfunction genetics
Cognitive Dysfunction pathology
Interleukin-1beta genetics
Polymorphism, Single Nucleotide genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1742-2094
- Volume :
- 9
- Database :
- MEDLINE
- Journal :
- Journal of neuroinflammation
- Publication Type :
- Academic Journal
- Accession number :
- 23199001
- Full Text :
- https://doi.org/10.1186/1742-2094-9-263