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Effect of superfine grinding on antidiabetic activity of bitter melon powder.
- Source :
-
International journal of molecular sciences [Int J Mol Sci] 2012 Nov 02; Vol. 13 (11), pp. 14203-18. Date of Electronic Publication: 2012 Nov 02. - Publication Year :
- 2012
-
Abstract
- The antidiabetic activities of bitter melon powders produced with lyophilization/superfine grinding and hot air drying/normal grinding were investigated in vivo for selecting a suitable bitter melon processing procedure. After a five-week treatment, bitter melon lyophilized superfine grinding powder (BLSP) had a higher antidiabetic activity with reducing fasting blood glucose levels from 21.40 to 12.54 mmol/L, the serum insulin levels from 40.93 to 30.74 mIU/L, and restoring activities of SOD compared with those in the bitter melon hot air drying powder (BAP) treated group. Furthermore, BLSP protected pancreatic tissues including islet beta cells and reduced the loss of islet cells. Combined with the difference of compositions in BLSP and BAP, it could be concluded that superfine grinding and lyophilization processes were beneficial for presenting the antidiabetic activity, which will provide a reference for direct utilization of bitter melon as a suitable functional food to relieve symptoms of diabetes.
- Subjects :
- Animals
Blood Glucose drug effects
Body Weight drug effects
Diabetes Mellitus, Experimental drug therapy
Diabetes Mellitus, Experimental metabolism
Diabetes Mellitus, Experimental pathology
Glutathione metabolism
Insulin blood
Lipids blood
Male
Pancreas metabolism
Pancreas pathology
Particle Size
Rats
Superoxide Dismutase metabolism
Hypoglycemic Agents administration & dosage
Hypoglycemic Agents chemistry
Momordica charantia chemistry
Powders administration & dosage
Powders chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1422-0067
- Volume :
- 13
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- International journal of molecular sciences
- Publication Type :
- Academic Journal
- Accession number :
- 23203059
- Full Text :
- https://doi.org/10.3390/ijms131114203