pH-responsive composite microspheres based on magnetic mesoporous silica nanoparticle for drug delivery.

Authors :: Wen H
Guo J
Chang B
Yang W
Source :: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V [Eur J Pharm Biopharm] 2013 May; Vol. 84 (1), pp. 91-8. Date of Electronic Publication: 2012 Nov 30.
Publication Year :: 2013
Abstract: pH-responsive composite microspheres, consisting of a core of Fe₃O₄ nanoparticle, a sandwiched layer of mesoporous silica and a shell of crosslinked poly (methacrylic acid) (PMAA), were successfully synthesized via distillation precipitation polymerization. The pKa of the composite microsphere increased with the increase in the crosslinking density. Doxorubicin hydrochloride (DOX) was applied as a model drug, and the behavior of drug storage/release was investigated. The cumulative release of DOX-loaded composite microsphere in vitro showed that the drug release rate was much faster below its pKa than that of above its pKa. Because pH of most tumor tissues was lower than that of normal tissues, the pH-responsive composite microspheres are promising drug delivery system especially for cancer therapy.<br /> (Copyright © 2012 Elsevier B.V. All rights reserved.)

Subjects :: Hydrogen-Ion Concentration
Nanoparticles chemistry
Silicon Dioxide chemistry
Drug Delivery Systems methods
Magnetics methods
Microspheres
Nanoparticles administration & dosage
Silicon Dioxide administration & dosage

Language :: English
ISSN :: 1873-3441
Volume :: 84
Issue :: 1
Database :: MEDLINE
Journal :: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
Publication Type :: Academic Journal
Accession number :: 23207322
Full Text :: https://doi.org/10.1016/j.ejpb.2012.11.019

Full Text Access

Tools