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Methylmercury induces CCL2 expression through activation of NF-κB in human 1321N1 astrocytes.
- Source :
-
The Journal of toxicological sciences [J Toxicol Sci] 2012; Vol. 37 (6), pp. 1275-8. - Publication Year :
- 2012
-
Abstract
- Methylmercury is an environmental pollutant that is toxic to the central nervous system; however, the molecular mechanisms underlying its toxicity remain unclear. Methylmercury increases expression of several chemokines in the cerebellum of mice treated with methylmercury. The present study analyzes the mechanism underlying methylmercury-induced chemokine expression using human 1321N1 astrocytes, and shows that methylmercury increases CCL2 expression in these cells. The transcription factor NF-κB is involved in the induction of chemokine expression. Methylmercury increased the level of the NF-κB p65 subunit in the nuclei of 1321N1 cells. The methylmercury-induced increase in CCL2 expression was significantly decreased by suppression of p65 expression by RNA interference. These results suggest that methylmercury induces chemokine expression through activation of NF-κB in human astrocytes.
Details
- Language :
- English
- ISSN :
- 1880-3989
- Volume :
- 37
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- The Journal of toxicological sciences
- Publication Type :
- Academic Journal
- Accession number :
- 23208443
- Full Text :
- https://doi.org/10.2131/jts.37.1275