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Curcumin inhibition of JNKs prevents dopaminergic neuronal loss in a mouse model of Parkinson's disease through suppressing mitochondria dysfunction.

Authors :
Pan J
Li H
Ma JF
Tan YY
Xiao Q
Ding JQ
Chen SD
Source :
Translational neurodegeneration [Transl Neurodegener] 2012 Aug 20; Vol. 1 (1), pp. 16. Date of Electronic Publication: 2012 Aug 20.
Publication Year :
2012

Abstract

Curcumin,a natural polyphenol obtained from turmeric,has been implicated to be neuroprotective in a variety of neurodegenerative disorders although the mechanism remains poorly understood. The results of our recent experiments indicated that curcumin could protect dopaminergic neurons from apoptosis in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of Parkinson's disease (PD). The death of dopaminergic neurons and the loss of dopaminergic axon in the striatum were significantly suppressed by curcumin in MPTP mouse model. Further studies showed that curcumin inhibited JNKs hyperphosphorylation induced by MPTP treatment. JNKs phosphorylation can cause translocation of Bax to mitochondria and the release of cytochrome c which both ultimately contribute to mitochondria-mediated apoptosis. These pro-apoptosis effect can be diminished by curcumin. Our experiments demonstrated that curcumin can prevent nigrostriatal degeneration by inhibiting the dysfunction of mitochondrial through suppressing hyperphosphorylation of JNKs induced by MPTP. Our results suggested that JNKs/mitochondria pathway may be a novel target in the treatment of PD patients.

Details

Language :
English
ISSN :
2047-9158
Volume :
1
Issue :
1
Database :
MEDLINE
Journal :
Translational neurodegeneration
Publication Type :
Academic Journal
Accession number :
23210631
Full Text :
https://doi.org/10.1186/2047-9158-1-16