Back to Search Start Over

Evaluation of the effect of genetic variations in GATA-4 on the phenprocoumon and acenocoumarol maintenance dose.

Authors :
van Schie RM
Wessels JA
Verhoef TI
Schalekamp T
le Cessie S
van der Meer FJ
Rosendaal FR
Visser LE
Teichert M
Hofman A
Buhre PN
de Boer A
Maitland-van der Zee AH
Source :
Pharmacogenomics [Pharmacogenomics] 2012 Dec; Vol. 13 (16), pp. 1917-23.
Publication Year :
2012

Abstract

Aim: To investigate whether the phenprocoumon and acenocoumarol maintenance doses are influenced by genetic variations in GATA-4, a transcription factor of CYP2C9.<br />Patients & Methods: The influence of seven GATA-4 SNPs on the coumarin maintenance dose was investigated by performing an analysis of variance trend analysis, stratified for CYP2C9 genotypes. Results of the best-explaining SNP were validated in the Rotterdam Study cohort.<br />Results: The largest dose differences were found for rs3735814 in patients using acenocoumarol and having the common allele for CYP2C9. The mean dosages decreased from 2.92 mg/day for the patients having the GATA-4 common alleles to 2.65 mg/day for the patients carrying one GATA-4 variant allele and to 2.37 mg/day for patients carrying two GATA-4 variant alleles (p = 0.004). Results could not be replicated in the validation cohort. For phenprocoumon, no significant effects were observed.<br />Conclusion: Genetic variation in GATA-4 does not seem relevant for clinical implementation.

Details

Language :
English
ISSN :
1744-8042
Volume :
13
Issue :
16
Database :
MEDLINE
Journal :
Pharmacogenomics
Publication Type :
Academic Journal
Accession number :
23215884
Full Text :
https://doi.org/10.2217/pgs.12.174