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New mycotoxins from marine-derived fungus Aspergillus sp. SCSGAF0093.
- Source :
-
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association [Food Chem Toxicol] 2013 Mar; Vol. 53, pp. 46-51. Date of Electronic Publication: 2012 Dec 05. - Publication Year :
- 2013
-
Abstract
- Nine mycotoxins including six aspergillic acid group toxins, aluminiumneoaspergillin (1), zirconiumneoaspergillin (2), aspergilliamide (3), ferrineoaspergillin (5), flavacol (6), neoaspergillic acid (7), and three ochratoxins, ochratoxin A n-butyl ester (4), ochratoxin A (8), ochratoxin A methyl ester (9), were isolated from the fermentation broth of marine gorgonian derived fungus Aspergillus sp. SCSGAF0093. Four of them (1-4) were new mycotoxins, and their structures were elucidated on the basis of spectroscopic analysis and chemical evidence. The bio-toxicity of compounds 1-9 were determined by brine shrimp lethality bioassay with median lethal concentration (LC(50)) values of 2.59-205.67 μM. This was the first report about zirconium complex obtained from nature and ochratoxins isolated from marine environment.<br /> (Copyright © 2012 Elsevier Ltd. All rights reserved.)
- Subjects :
- Animals
Anthozoa chemistry
Aquatic Organisms
Artemia drug effects
Biological Assay methods
Environmental Monitoring methods
Fermentation
Lethal Dose 50
Molecular Structure
Mycotoxins toxicity
Ochratoxins analysis
Pyrazines toxicity
Water Pollutants, Chemical toxicity
Zirconium isolation & purification
Zirconium toxicity
Aspergillus metabolism
Mycotoxins isolation & purification
Pyrazines isolation & purification
Water Pollutants, Chemical isolation & purification
Subjects
Details
- Language :
- English
- ISSN :
- 1873-6351
- Volume :
- 53
- Database :
- MEDLINE
- Journal :
- Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
- Publication Type :
- Academic Journal
- Accession number :
- 23220611
- Full Text :
- https://doi.org/10.1016/j.fct.2012.11.037