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Organometallic anticancer agents that interfere with cellular energy processes: a subtle approach to inducing cancer cell death.
- Source :
-
Dalton transactions (Cambridge, England : 2003) [Dalton Trans] 2013 Feb 21; Vol. 42 (7), pp. 2347-50. Date of Electronic Publication: 2012 Dec 05. - Publication Year :
- 2013
-
Abstract
- Two hybrid compounds comprising an antimetastatic ruthenium-arene fragment tethered to an indazole-3-carboxylic acid derivative that inhibits aerobic glycolysis in cancer cells have been prepared and evaluated in a variety of cancer cell lines, including highly relevant human glioblastoma cells, with an apparent synergistic action between the two components observed.
- Subjects :
- Antineoplastic Agents chemical synthesis
Antineoplastic Agents chemistry
Cell Death drug effects
Cell Line, Tumor
Dose-Response Relationship, Drug
Drug Screening Assays, Antitumor
Humans
Models, Molecular
Molecular Structure
Organometallic Compounds chemical synthesis
Organometallic Compounds chemistry
Structure-Activity Relationship
Antineoplastic Agents pharmacology
Neoplasms drug therapy
Neoplasms pathology
Organometallic Compounds pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1477-9234
- Volume :
- 42
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Dalton transactions (Cambridge, England : 2003)
- Publication Type :
- Academic Journal
- Accession number :
- 23223548
- Full Text :
- https://doi.org/10.1039/c2dt31936e