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Mesenteric neovascularization with distraction-induced intestinal growth: enterogenesis.
- Source :
-
Pediatric surgery international [Pediatr Surg Int] 2013 Jan; Vol. 29 (1), pp. 33-9. - Publication Year :
- 2013
-
Abstract
- Background: Distraction-induced enterogenesis, whereby the intestine lengthens with application of linear forces, is an emerging area which may provide a unique treatment for short bowel syndrome. With an increase in overall tissue mass, there is an increase in oxygen and nutrient demand. We hypothesized that a neovascularization within the mesentery is necessary to support the growing small bowel.<br />Methods: A curvilinear hydraulic device was used to induce growth within the small bowel of Yorkshire pigs, and the intestine was harvested after 14 days. High-resolution gross pictures were recorded of the mesentery at implantation and at harvest, and CT imaging of the bowel and mesentery was performed at harvest after dye injection.<br />Results: After 2 weeks of distraction, an average of 72.5 % (8.7 cm) bowel lengthening was achieved. Gross images of the mesentery between major vessels showed a blossoming of the microvasculature and this was confirmed by CT imaging with 3D reconstruction. Mesenteric sample taken from the distracted segment had a fourfold increase in the volume of microvasculature versus controls.<br />Conclusion: Enterogenesis results not only in increased bowel length, but also significant increase in the mesenteric microvascularity. Presumably, this sustains the lengthened segment after application of longitudinal forces.
Details
- Language :
- English
- ISSN :
- 1437-9813
- Volume :
- 29
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Pediatric surgery international
- Publication Type :
- Academic Journal
- Accession number :
- 23229341
- Full Text :
- https://doi.org/10.1007/s00383-012-3204-5