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Imaging impulse control disorders in Parkinson's disease and their relationship to addiction.
- Source :
-
Journal of neural transmission (Vienna, Austria : 1996) [J Neural Transm (Vienna)] 2013 Apr; Vol. 120 (4), pp. 659-64. Date of Electronic Publication: 2012 Dec 12. - Publication Year :
- 2013
-
Abstract
- Established substance addictions and impulse control disorders (ICDs) such as pathological gambling share similar underlying neurobiology, and recent data extends these commonalities to the risk factors that increase an individuals' susceptibility to develop such behaviours. In Parkinson's disease (PD), impulse control disorders (ICDs) are increasingly recognised to develop after patients begin dopamine (DA) restoration therapy, in particular DA agonists. In both the PD and non-PD population, more impulsive individuals are at increased risk for impulse control disorders. Here, we review the neuroimaging data confirming the connection between addiction and ICDs, and revealing how DA agonists might cause specific alterations of basal ganglia and cortical function that vary as a function of an individuals' propensity for impulsivity.
- Subjects :
- Behavior, Addictive complications
Brain metabolism
Disruptive, Impulse Control, and Conduct Disorders complications
Humans
Impulsive Behavior
Parkinson Disease physiopathology
Behavior, Addictive physiopathology
Brain physiopathology
Disruptive, Impulse Control, and Conduct Disorders physiopathology
Dopamine metabolism
Neuroimaging
Parkinson Disease complications
Subjects
Details
- Language :
- English
- ISSN :
- 1435-1463
- Volume :
- 120
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Journal of neural transmission (Vienna, Austria : 1996)
- Publication Type :
- Academic Journal
- Accession number :
- 23232664
- Full Text :
- https://doi.org/10.1007/s00702-012-0933-5