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Temperature-driven self-actuated microchamber sealing system for highly integrated microfluidic devices.
- Source :
-
Lab on a chip [Lab Chip] 2013 Feb 07; Vol. 13 (3), pp. 452-8. - Publication Year :
- 2013
-
Abstract
- We present here a novel microchamber sealing valve that is self-actuated by a pressure change during the temperature change in the thermal activation of reactions. Actuation of our valve requires only the use of the same heating device as employed for the reactions. A thermoplastic UV-curable polymer is used as a device material; the polymer allows realization of the temperature-driven valve actuation as well as the fabrication of multi-layered devices. The self-actuated valve achieves effective sealing of the microchamber for the polymerase chain reaction (PCR) even at 90 °C, which is essential for developing highly parallel PCR array devices without the need for complicated peripherals to control the valve operation.
Details
- Language :
- English
- ISSN :
- 1473-0189
- Volume :
- 13
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Lab on a chip
- Publication Type :
- Academic Journal
- Accession number :
- 23235490
- Full Text :
- https://doi.org/10.1039/c2lc41030c