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Long-term outcomes of hematopoietic stem cell transplantation for severe treatment-resistant autoimmune cytopenia in children.
- Source :
-
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation [Biol Blood Marrow Transplant] 2013 Apr; Vol. 19 (4), pp. 666-9. Date of Electronic Publication: 2012 Dec 16. - Publication Year :
- 2013
-
Abstract
- We analyzed the long-term outcomes of pediatric patients registered in the European Group for Blood and Marrow Transplantation database who underwent hematopoietic stem cell transplantation (HSCT) for severe treatment refractory autoimmune cytopenia. With a median follow-up of 100 months, event-free survival was 54% overall, with no significant difference between allogeneic HSCT (n = 15) and autologous HSCT (n = 7) recipients (58% versus 42%; P = .50). Despite a trend toward failure of response or relapse after autologous HSCT compared with allogeneic HSCT, the difference was not significant (43% versus 13%; P = .30). Treatment-related mortality was high in both HSCT groups (29% and 16%; P = .09). Based on the limited numbers of subjects in this retrospective analysis, both allogeneic and autologous HSCT may induce complete and persistent responses in approximately one-half of pediatric patients with severe refractory autoimmune cytopenia, although treatment-related toxicity is high.<br /> (Copyright © 2013 American Society for Blood and Marrow Transplantation. Published by Elsevier Inc. All rights reserved.)
- Subjects :
- Adolescent
Autoimmune Diseases immunology
Autoimmune Diseases pathology
Child
Child, Preschool
Female
Humans
Infant
Male
Neutropenia immunology
Neutropenia pathology
Recurrence
Retrospective Studies
Survival Analysis
Thrombocytopenia immunology
Thrombocytopenia pathology
Transplantation, Autologous
Transplantation, Homologous
Treatment Outcome
Autoimmune Diseases therapy
Hematopoietic Stem Cell Transplantation
Neutropenia therapy
Thrombocytopenia therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1523-6536
- Volume :
- 19
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation
- Publication Type :
- Academic Journal
- Accession number :
- 23253561
- Full Text :
- https://doi.org/10.1016/j.bbmt.2012.12.008