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CSF high-mobility group box 1 is associated with intrathecal inflammation and astrocytic damage in neuromyelitis optica.
- Source :
-
Journal of neurology, neurosurgery, and psychiatry [J Neurol Neurosurg Psychiatry] 2013 May; Vol. 84 (5), pp. 517-22. Date of Electronic Publication: 2012 Dec 19. - Publication Year :
- 2013
-
Abstract
- Objective: High-mobility group box 1 (HMGB1) acts as a proinflammatory mediator when released by cells. Recent studies implicate extracellular HMGB1 in the pathogenesis of various autoimmune diseases. Our main aim of this study is to determine whether HMGB1 is involved in the neuromyelitis optica (NMO) inflammatory process.<br />Methods: Cerebrospinal fluid (CSF) and serum HMGB1 levels in 42 NMO patients were compared with those in 30 multiple sclerosis (MS) patients, and 30 patients with other noninflammatory neurological disorders (ONNDs). We also tested the possible correlation between CSF HMGB1 levels and the clinical and laboratory variables in NMO patients.<br />Results: CSF HMGB1 levels in NMO patients were higher than those in MS and ONNDs patients (p<0.001), and these levels in MS patients were higher than those in ONNDs patients (p<0.001). After treatment, the CSF HMGB1 levels in NMO patients decreased to normal. In addition, CSF HMGB1 levels correlated with CSF cell counts, CSF protein levels, CSF interleukin-6 levels, CSF glial fibrillary acidic protein levels, and CSF/serum albumin ratio (p≤0.001). Serum HMGB1 levels in MS patients were significantly higher than those in ONNDs patients (p=0.002).<br />Conclusions: HMGB1 could play a key role in central nervous system inflammation in NMO patients.
- Subjects :
- Adolescent
Adult
Aged
Aged, 80 and over
Anti-Inflammatory Agents therapeutic use
Disability Evaluation
Female
Glial Fibrillary Acidic Protein cerebrospinal fluid
HMGB1 Protein blood
Humans
Immunosuppressive Agents therapeutic use
Interleukin-6 cerebrospinal fluid
Male
Middle Aged
Multiple Sclerosis cerebrospinal fluid
Multiple Sclerosis genetics
Multiple Sclerosis pathology
Myelitis blood
Nervous System Diseases cerebrospinal fluid
Nervous System Diseases pathology
Young Adult
Astrocytes pathology
HMGB1 Protein cerebrospinal fluid
Myelitis cerebrospinal fluid
Myelitis pathology
Neuromyelitis Optica cerebrospinal fluid
Neuromyelitis Optica pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1468-330X
- Volume :
- 84
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Journal of neurology, neurosurgery, and psychiatry
- Publication Type :
- Academic Journal
- Accession number :
- 23255728
- Full Text :
- https://doi.org/10.1136/jnnp-2012-304039