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Multicenter study of endoscopic mucosal resection using 0.13% hyaluronic acid solution of colorectal polyps less than 20 mm in size.
- Source :
-
International journal of colorectal disease [Int J Colorectal Dis] 2013 Jul; Vol. 28 (7), pp. 985-91. Date of Electronic Publication: 2012 Dec 28. - Publication Year :
- 2013
-
Abstract
- Purpose: Endoscopic mucosal resection (EMR) of colorectal polyps should be curative and safe. This study aimed to determine the efficacy and safety of colorectal EMR using 0.13% hyaluronic acid (HA) solution.<br />Methods: This was a single-armed multicenter prospective open trial conducted at 11 Japanese institutions. Lesion characteristics and various measures of clinical outcome, including en bloc resection, histopathologically complete resection, and postoperative bleeding were analyzed for 624 consecutive patients who underwent EMR of colorectal polyps at ≤20 mm in size from August 2010 to September 2011.<br />Results: En bloc and complete resection were achieved in 93.3 and 78.3% of 624 lesions. The median EMR procedure time was 2.1 ± 1.5 min. The rates of postoperative bleeding and perforation were 1.1 and 0%. The rate of en bloc resection was higher for polyps at 5-10 mm than for polyps at 11-20 mm (95.1 vs. 85.1%; P < 0.001) and was higher for protruding polyps than for superficial polyps (94.5 vs. 87.1%; P < 0.05). The rate of en bloc resection was also higher for polyps in the left-side colon than for those in the right-side colon or rectum (96.7 vs. 91.6 vs. 90.8%; P < 0.05). Multivariate analysis showed that polyp at 11-20 mm in size and location not on the left-side colon was significantly independent risk factors for failure of en bloc resection.<br />Conclusion: EMR using 0.13% HA of colorectal polyps less than 20 mm in size had high rates of en bloc and complete resection and few complications.
- Subjects :
- Adult
Aged
Aged, 80 and over
Female
Humans
Hyaluronic Acid administration & dosage
Intestinal Mucosa drug effects
Intestinal Mucosa pathology
Intestinal Polyps pathology
Male
Middle Aged
Multivariate Analysis
Rectum drug effects
Rectum pathology
Rectum surgery
Risk Factors
Solutions
Young Adult
Colonoscopy
Hyaluronic Acid pharmacology
Intestinal Mucosa surgery
Intestinal Polyps surgery
Subjects
Details
- Language :
- English
- ISSN :
- 1432-1262
- Volume :
- 28
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- International journal of colorectal disease
- Publication Type :
- Academic Journal
- Accession number :
- 23271496
- Full Text :
- https://doi.org/10.1007/s00384-012-1631-3