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Role of (18)F-fluorodeoxyglucose positron emission tomography/computed tomography in the characterization of pancreatic masses: experience from tropics.
- Source :
-
Journal of gastroenterology and hepatology [J Gastroenterol Hepatol] 2013 Feb; Vol. 28 (2), pp. 255-61. - Publication Year :
- 2013
-
Abstract
- Background and Aim: Early detection and differentiation of malignant from benign pancreatic tumors is very essential as mass-forming pancreatitis is a frequently encountered problem. Positron emission tomography (PET) has a role in establishing the diagnosis of pancreatic carcinoma when the conventional imaging modalities or biopsies are nondiagnostic. In this prospective study, the utility of fluorodeoxyglucose (FDG)-PET/computed tomography (CT) in the characterization of mass-forming lesions of the pancreas was reported.<br />Methods: (18)F-FDG-PET/CT was prospectively performed in 87 patients diagnosed to have periampullary or pancreatic mass. Lesions with focally increased FDG uptake in PET/CT were considered malignant, whereas those with diffuse or no FDG uptake were considered benign. Semiquantitative analysis with maximum standardized uptake value (SUVmax) was also calculated. The PET/CT results were compared with histopathological results in all patients.<br />Results: Based on the FDG uptake pattern, sensitivity, specificity, positive predictive value, negative predictive value, and accuracy for FDG-PET/CT in characterizing the periampullary and pancreatic masses into benign and malignant lesions were 93%, 90%, 95%, 87%, and 92% respectively. Receiver operating characteristics curve analysis of the SUVmax of the lesions yielded a cut-off value of 2.8, with a sensitivity and specificity of 87.5% and 45% respectively.<br />Conclusion: The FDG uptake pattern in PET/CT can differentiate malignant from benign mass-forming lesions of the pancreas with high accuracy and a discrete cut-off value of SUVmax could not be defined for the same as even lesions with pancreatic tuberculosis showed very high FDG uptake. Hence, in patients with a suspicion of malignancy in the pancreas, a focally increase FDG uptake in PET/CT suggests the diagnosis of malignancy.<br /> (© 2012 Journal of Gastroenterology and Hepatology Foundation and Wiley Publishing Asia Pty Ltd.)
- Subjects :
- Adult
Aged
Aged, 80 and over
Area Under Curve
Diagnosis, Differential
Early Detection of Cancer
Female
Humans
India
Male
Middle Aged
Pancreatic Neoplasms pathology
Predictive Value of Tests
Prospective Studies
ROC Curve
Fluorodeoxyglucose F18
Multimodal Imaging
Pancreatic Neoplasms diagnostic imaging
Positron-Emission Tomography
Radiopharmaceuticals
Tomography, X-Ray Computed
Subjects
Details
- Language :
- English
- ISSN :
- 1440-1746
- Volume :
- 28
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Journal of gastroenterology and hepatology
- Publication Type :
- Academic Journal
- Accession number :
- 23278193
- Full Text :
- https://doi.org/10.1111/jgh.12068