Improved high-fat diet-induced glucose intolerance by an oral administration of phytosphingosine.

Authors :: Murakami I
Mitsutake S
Kobayashi N
Matsuda J
Suzuki A
Shigyo T
Igarashi Y
Source :: Bioscience, biotechnology, and biochemistry [Biosci Biotechnol Biochem] 2013; Vol. 77 (1), pp. 194-7. Date of Electronic Publication: 2013 Jan 07.
Publication Year :: 2013
Abstract: We have previously reported that phytoceramide and phytosphingosine (PHS) stimulated the transcriptional activity of peroxisome proliferator-activated receptor γ (PPARγ) in cells. PPARγ is a therapeutic target for type 2 diabetes. We found in this study that an oral administration of PHS improved diet-induced glucose intolerance in mice. Since PHS is highly expressed in yeast, PHS in fermented foods may improve diabetes.

Subjects :: Adiponectin genetics
Adiponectin metabolism
Administration, Oral
Animals
Body Weight drug effects
Chemokine CCL2 genetics
Chemokine CCL2 metabolism
Diabetes Mellitus, Type 2 etiology
Diet, High-Fat adverse effects
Gene Expression
Glucose Intolerance prevention & control
Glucose Tolerance Test
Intestine, Small chemistry
Liver chemistry
Mice
Mice, Knockout
Multienzyme Complexes deficiency
Multienzyme Complexes genetics
Oxidoreductases deficiency
Oxidoreductases genetics
PPAR gamma genetics
PPAR gamma metabolism
Sphingosine administration & dosage
Tumor Necrosis Factor-alpha genetics
Tumor Necrosis Factor-alpha metabolism
Ceramides administration & dosage
Diabetes Mellitus, Type 2 diet therapy
Diabetes Mellitus, Type 2 metabolism
Glucose metabolism
Intestine, Small metabolism
Liver metabolism
Sphingosine analogs & derivatives

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